Animal bone meal as a new efficient heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

被引：0

作者：

Azzallou, Rachid ^{[1
,2
]}

Talebb, Mohamed Ait ^{[2
,3
]}

Mamouni, Rachid ^{[2
]}

Lazar, Said ^{[1
]}

Benlhachemi, Abdeljalil ^{[4
]}

Bakiz, Bahcine ^{[4
]}

Villain, Sylvie ^{[5
]}

机构：

[1] Mohammedia Univ Hassan II Casablanca, Lab Biochim Environm & Agroalimentaire, URAC 36, Fac Sci & Tech, Mohammadia, Morocco

[2] Univ Ibn Zohr, Fac Sci, Equipe Mat Catalyse & Valorisat Ressources Nat, BP 8106, Agadir, Morocco

[3] Univ Ibn Zohr, Equipe Chim Bioorgan Appl, Fac Sci, BP 8106, Agadir, Morocco

[4] Univ Ibn Zohr, LME, Fac Sci, BP 8106, Agadir, Morocco

[5] Univ Toulon & Var, Aix Marseille Univ, CNRS, Inst Mat Microelect & Nanosci Provence,UMR IM2NP, F-83957 La Garde, France

来源：

MOROCCAN JOURNAL OF CHEMISTRY | 2019年 / 7卷 / 02期

关键词：

Animal Bone Meal; 3,4-dihydropyrimidin-2(1H)-ones/thiones; Biginelli reaction; beta-ketoester; urea; microwave (MW); CALCIUM-CHANNEL BLOCKERS; ONE-POT SYNTHESIS; ACID-ESTERS; FLUORAPATITE; BEHAVIOR; CHLORIDE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Animal bone meal has been used as an efficient catalyst for an improved and rapid one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones and their derivatives through three-component condensation reactions of aldehyde, beta-ketoester, and urea or thiourea in excellent yields. This catalyst was found to be highly active and selective, affording a high yield of 3,4-dihydropyrimidin-2(1H)-ones/thiones. These reactions were performed via conventional heating in water or under microwave irradiation. Compared to the classical Biginelli reaction conditions, this new approach consistently has the advantage of excellent yields, short reaction times, simple and convenient procedure, inexpensive reagents and eco-friendly preparation.

引用

页码：254 / 264

页数：11

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