Dihydrothiophene-condensed chromones from a marine-derived fungus Penicillium oxalicum and their structure-bioactivity relationship

被引：35

作者：

Bao, Jie ^{[1
,2
]}

Luo, Jin-Feng ^{[3
]}

Qin, Xiao-Chu ^{[3
]}

Xu, Xin-Ya ^{[1
]}

Zhang, Xiao-Yong ^{[1
]}

Tu, Zheng-Chao ^{[3
]}

Qi, Shu-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 11期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Penicillium oxalicum; Dihydrothiophene-condensed chromones; Cytotoxicity; Structure-bioactivity relationship;

D O I：

10.1016/j.bmcl.2014.04.028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D-E (1-2) and known oxalicumones A-B (3-4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1-2 were elucidated by spectroscopic analysis. Eleven derivatives 3a-3i and 4a-4b were obtained from the acylation of 3 and 4, respectively. Compounds 1-4, 3a-3e, 3g-3h, and 4b showed significant cytotoxicity against several carcinoma cell lines with IC50 <= 10 mu M. And their structure-bioactivity relationship was discussed. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2433 / 2436

页数：4

共 11 条

[1] Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023 [J].