Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects

被引：25

作者：

Khokhlova, Tatiana D. ^{[2
]}

Haider, Yasser ^{[3
]}

Hwang, Joo Ha ^{[1
]}

机构：

[1] Univ Washington, Div Gastroenterol, Dept Med, Med, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA 98104 USA

[3] Univ Washington, Dept Urol, Seattle, WA 98104 USA

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2015年 / 8卷 / 06期

关键词：

liver tumors; microbubbles; oncology; pancreatic cancer; review; ultrasound; INTENSITY FOCUSED ULTRASOUND; HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; GENE DELIVERY; CONTRAST AGENTS; DRUG-DELIVERY; ECHOGENIC LIPOSOMES; LIVER METASTASES; SONOPORATION; TUMOR;

D O I：

10.1177/1756283X15592584

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Microbubbles were initially invented as contrast agents for ultrasound imaging. However, lately more and more therapeutic applications of microbubbles are emerging, mostly related to drug and gene delivery. Ultrasound is a safe and noninvasive therapeutic modality which has the unique ability to interact with microbubbles and release their payload in situ in addition to permeabilizing the target tissues. The combination of drug-loaded microbubbles and ultrasound has been used in preclinical studies on blood-brain barrier opening, drug and gene delivery to solid tumors, and ablation of blood vessels. This review covers the basic principles of ultrasound-microbubble interaction, the types of microbubbles and the effect they have on tissue, and the preclinical and clinical experience with this approach to date in the field of gastrointestinal oncology.

引用

页码：384 / 394

页数：11

共 45 条

[1] The Oncosurgery Approach to Managing Liver Metastases from Colorectal Cancer: A Multidisciplinary International Consensus [J].

Adam, Rene ;

De Gramont, Aimery ;

Figueras, Joan ;

Guthrie, Ashley ;

Kokudo, Norihiro ;

Kunstlinger, Francis ;

Loyer, Evelyne ;

Poston, Graeme ;

Rougier, Philippe ;

Rubbia-Brandt, Laura ;

Sobrero, Alberto ;

Tabernero, Josep ;

Teh, Catherine ;

Van Cutsem, Eric .

ONCOLOGIST, 2012, 17 (10) :1225-1239

[2] Blood Vessel Deformations on Microsecond Time Scales by Ultrasonic Cavitation [J].

Chen, Hong ;

Kreider, Wayne ;

Brayman, Andrew A. ;

Bailey, Michael R. ;

Matula, Thomas J. .

PHYSICAL REVIEW LETTERS, 2011, 106 (03)

[3] Disposition of Ultrasound Sensitive Polymeric Drug Carrier in a Rat Hepatocellular Carcinoma Model [J].

Cochran, Michael C. ;

Eisenbrey, John R. ;

Soulen, Michael C. ;

Schultz, Susan M. ;

Ouma, Richard O. ;

White, Sarah B. ;

Furth, Emma E. ;

Wheatley, Margaret A. .

ACADEMIC RADIOLOGY, 2011, 18 (11) :1341-1348

[4] Optical and acoustical observations of the effects of ultrasound on contrast agents [J].

Dayton, PA ;

Morgan, KE ;

Klibanov, AL ;

Brandenburger, GH ;

Ferrara, KW .

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 1999, 46 (01) :220-232

[5] Development and optimization of a doxorubicin loaded poly(lactic acid) contrast agent for ultrasound directed drug delivery [J].

Eisenbrey, J. R. ;

Burstein, O. Mualem ;

Kambhampati, R. ;

Forsberg, F. ;

Liu, J. -B. ;

Wheatley, M. A. .

JOURNAL OF CONTROLLED RELEASE, 2010, 143 (01) :38-44

[6] Hepatocellular carcinoma [J].

Forner, Alejandro ;

Llovet, Josep M. ;

Bruix, Jordi .

LANCET, 2012, 379 (9822) :1245-1255

[7]

GABIZON A, 1994, CANCER RES, V54, P987

[8] A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics Adriamycin and daunorubicin [J].

Gewirtz, DA .

BIOCHEMICAL PHARMACOLOGY, 1999, 57 (07) :727-741

[9]

Goldberg BB, 2001, Ultrasound Contrast Agents: Basic Principles and Clinical Applications, V2nd

[10]

Gramiak R, 1968, Invest Radiol, V3, P356

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