Evaluation of FTIR spectroscopy as diagnostic tool for colorectal cancer using spectral analysis

被引：75

作者：

Dong, Liu ^{[1
]}

Sun, Xuejun ^{[1
]}

Chao, Zhang ^{[1
]}

Zhang, Shiyun ^{[1
]}

Zheng, Jianbao ^{[1
]}

Gurung, Rajendra ^{[1
]}

Du, Junkai ^{[1
]}

Shi, Jingsen ^{[1
]}

Xu, Yizhuang ^{[2
]}

Zhang, Yuanfu ^{[2
]}

Wu, Jinguang ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Gen Surg, Xian 710061, Shaanxi Provinc, Peoples R China

[2] Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 122卷

关键词：

FTIR spectroscopy; Colorectal cancerl; Principal component analysis; Spectrum; TRANSFORM INFRARED-SPECTROSCOPY; GALLBLADDER CARCINOMA-CELL; ATR; BIOMARKER; TISSUE;

D O I：

10.1016/j.saa.2013.11.031

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The aim of this study is to confirm FTIR spectroscopy as a diagnostic tool for colorectal cancer. 180 freshly removed colorectal samples were collected from 90 patients for spectrum analysis. The ratios of spectral intensity and relative intensity (/I1460) were calculated. Principal component analysis (PCA) and Fisher's discriminant analysis (FDA) were applied to distinguish the malignant from normal. The FTIR parameters of colorectal cancer and normal tissues were distinguished due to the contents or configurations of nucleic acids, proteins, lipids and carbohydrates. Related to nitrogen containing, water, protein and nucleic acid were increased significantly in the malignant group. Six parameters were selected as independent factors to perform discriminant functions. The sensitivity for FTIR in diagnosing colorectal cancer was 96.6% by discriminant analysis. Our study demonstrates that FTIR can be a useful technique for detection of colorectal cancer and may be applied in clinical colorectal cancer diagnosis. (C) 2013 Published by Elsevier B.V.

引用

页码：288 / 294

页数：7

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