Signalling Properties of Inositol Polyphosphates

被引：13

作者：

Maffucci, Tania ^{[1
]}

Falasca, Marco ^{[2
]}

机构：

[1] Queen Mary Univ London, Ctr Cell Biol & Cutaneous Res, Blizard Inst, Barts & London Sch Med & Dent, London E1 2AT, England

[2] Curtin Univ, CHIRI, Sch Pharm & Biomed Sci, Perth, WA 6102, Australia

来源：

MOLECULES | 2020年 / 25卷 / 22期

关键词：

inositol phosphates; cell signaling; experimental pharmacology; pleckstrin homology domain; inositol; 1; 3; 4; 5; 6-pentakisphosphate; 2; 6-hexakisphosphate; HEXAPHOSPHATE INHIBITS GROWTH; PHOSPHATE MULTIKINASE; APOPTOTIC DEATH; PROTEIN-KINASE; HUMAN HOMOLOG; CANCER CELLS; G1; ARREST; HEXAKISPHOSPHATE; IP6; BINDING;

D O I：

10.3390/molecules25225281

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led to the accumulation of new information regarding their cellular roles as well as new insights into their cellular production. These studies have revealed that interaction of IPs with several proteins is critical for stabilization of protein complexes and for modulation of enzymatic activity. This has not only revealed their importance in regulation of several cellular processes but it has also highlighted the possibility of new pharmacological interventions in multiple diseases, including cancer. In this review, we describe some of the intracellular roles of IPs and we discuss the pharmacological opportunities that modulation of IPs levels can provide.

引用

页数：13

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