Y-box binding protein 1-A prognostic marker and target in tumour therapy

被引：98
作者：
Kosnopfel, Corinna [1 ]
Sinnberg, Tobias [1 ]
Schittek, Birgit [1 ]
机构：
[1] Univ Tubingen, Dept Dermatol, Div Dermatooncol, D-72076 Tubingen, Germany
来源：
EUROPEAN JOURNAL OF CELL BIOLOGY | 2014年 / 93卷 / 1-2期
关键词：
Oncogene; Transcription factor; Translational regulation; DNA repair; Proliferation; Survival; Migration/invasion; Chemoresistance; Angiogenesis; Genomic instability; MESSENGER-RIBONUCLEOPROTEIN PARTICLES; STAGE EMBRYONIC-DEVELOPMENT; STRESS-INDUCED ACTIVATION; RESISTANT CANCER-CELLS; RIBOSOMAL S6 KINASE; NUCLEAR EXPRESSION; YB-1; EXPRESSION; P-GLYCOPROTEIN; DRUG-RESISTANCE; GENE-EXPRESSION;
D O I：
10.1016/j.ejcb.2013.11.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes including both transcriptional and translational regulation of target gene expression. Significantly increased YB-1 levels have been reported in a number of human malignancies and shown to be associated with poor prognosis and disease recurrence. Indeed, YB-1 can act as a versatile oncoprotein playing an important role in tumour cell proliferation and progression. Consequently, YB-1 not only proves to be a good prognostic tumour marker, but also may be a promising emerging molecular target for the development of new therapeutical strategies. In this review, we discuss both the role of YB-1 in cancer and specifically in malignant melanoma as well as possible translations into the clinics derived thereof. (C) 2014 Elsevier GmbH. All rights reserved.
引用
收藏
页码：61 / 70
页数：10
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