Fatty acid synthase: a new anti-tumor target

被引：6
|
作者：
Puig, Teresa [1 ,2 ]
Porta, Rut [1 ]
Colomer, Ramon [1 ,3 ]
机构：
[1] Hosp Univ Dr Josep Trueta, Inst Invest Biomed Girona IdIBGi, Inst Catalan Oncol ICO Girona, Girona, Spain
[2] Univ Girona UdG, Fac Med, Girona, Spain
[3] Ctr Oncol MD Anderson Espana, Madrid, Spain
来源：
MEDICINA CLINICA | 2009年 / 132卷 / 09期
关键词：
Cancer; Fatty acid metabolism; Fatty acid synthase; New antitumor drugs; COA-CARBOXYLASE-ALPHA; BREAST-CANCER CELLS; PROSTATE-CANCER; GREEN TEA; THERAPEUTIC TARGET; FAS EXPRESSION; INCREASED RISK; FOOD-INTAKE; INHIBITION; ACTIVATION;
D O I：
10.1016/j.medcli.2008.07.022
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Fatty acid synthase (FASN), an enzyme capable of de novo fatty acid synthesis, is highly expressed and activated in most human carcinomas. FASN is associated with poor prognosis in prostate and breast cancer and its inhibition is selectively cytotoxic to human cancer cells. Thus, FASN and fatty acid metabolism have become an important focus for the diagnostic and treatment of cancer. In this sense, there is an increasing interest in identifying and developing new antitumor compounds that inhibit FASN. (C) 2008 Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：359 / 363
页数：5
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