Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma

被引：12
作者：
Song, Hao [1 ]
Wang, Lizhen [2 ]
Lyu, Jiong [3 ]
Wu, Yunteng [1 ]
Guo, Wei [1 ]
Ren, Guoxin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai 200011, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral Pathol, Shanghai 200011, Peoples R China
[3] Zhejiang Univ, Dept Stomatol, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 17期
关键词：
oral mucosa; melanoma; BAP1; prognosis; immunohistochemistry; PRIMARY MALIGNANT-MELANOMA; OF-THE-LITERATURE; UVEAL MELANOMA; UBIQUITIN HYDROLASE; NECK DISSECTION; MUTATIONS; TUMORS; HEAD; IMMUNOHISTOCHEMISTRY; INHIBITORS;
D O I：
10.18632/oncotarget.16175
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, loss of nuclear BAP1 expression was associated with poor overall survival (P < 0.001, Log-rank = 21.308) and distant metastasis (P = 0.034, OR = 0.320). Multivariate analysis showed BAP1 to be an independent prognostic factor (P = 0.027, HR = 0.479). It thus appears that loss of nuclear BAP1 expression is an independent prognostic factor of poor overall survival and associated with distant metastasis in OMM.
引用
收藏
页码：29080 / 29090
页数：11
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