Loss of nuclear BAP1 expression is associated with poor prognosis in oral mucosal melanoma

被引：12
作者：
Song, Hao [1 ]
Wang, Lizhen [2 ]
Lyu, Jiong [3 ]
Wu, Yunteng [1 ]
Guo, Wei [1 ]
Ren, Guoxin [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai 200011, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral Pathol, Shanghai 200011, Peoples R China
[3] Zhejiang Univ, Dept Stomatol, Sch Med, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 17期
关键词：
oral mucosa; melanoma; BAP1; prognosis; immunohistochemistry; PRIMARY MALIGNANT-MELANOMA; OF-THE-LITERATURE; UVEAL MELANOMA; UBIQUITIN HYDROLASE; NECK DISSECTION; MUTATIONS; TUMORS; HEAD; IMMUNOHISTOCHEMISTRY; INHIBITORS;
D O I：
10.18632/oncotarget.16175
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Oral mucosal melanoma (OMM) is an aggressive neoplasm with an extremely poor prognosis. BAP1 is a tumor suppressor that has been associated with the outcome of melanomas and other malignancies. In this study, we investigated the genetic alterations in BAP1 and the prognostic potential of BAP1 protein expression in oral mucosal melanoma. DNA sequence analysis of BAP1 from 12 OMM patient samples revealed missense mutations in the tissues from four patients. Based on immunohistochemical staining, loss of nuclear BAP1 expression was associated with poor overall survival (P < 0.001, Log-rank = 21.308) and distant metastasis (P = 0.034, OR = 0.320). Multivariate analysis showed BAP1 to be an independent prognostic factor (P = 0.027, HR = 0.479). It thus appears that loss of nuclear BAP1 expression is an independent prognostic factor of poor overall survival and associated with distant metastasis in OMM.
引用
收藏
页码：29080 / 29090
页数：11
相关论文
共 50 条
  • [1] Loss of nuclear BAP1 protein expression is a marker of poor prognosis in patients with clear cell renal cell carcinoma
    Minardi, Daniele
    Lucarini, Guendalina
    Milanese, Giulio
    Di Primio, Roberto
    Montironi, Rodolfo
    Muzzonigro, Giovanni
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2016, 34 (08) : 338.e11 - 338.e18
  • [2] Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma
    Jama, N.
    Farquhar, N.
    Butt, Z.
    Coupland, S. E.
    Sacco, J. J.
    Scase, T.
    Fielding, A. B.
    Coulson, J. M.
    Kalirai, H.
    Killick, D. R.
    JOURNAL OF COMPARATIVE PATHOLOGY, 2018, 162 : 50 - 58
  • [3] Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma
    Andrici, Juliana
    Goeppert, Benjamin
    Sioson, Loretta
    Clarkson, Adele
    Renner, Marcus
    Stenzinger, Albrecht
    Tayao, Michael
    Watson, Nicole
    Farzin, Mahtab
    Toon, Christopher W.
    Smith, Ross C.
    Mittal, Anubhav
    Samra, Jaswinder S.
    Hugh, Thomas J.
    Chou, Angela
    Lawlor, Rita T.
    Weichert, Wilko
    Schirmacher, Peter
    Sperandio, Nicola
    Ruzzenente, Andrea
    Scarpa, Aldo
    Gill, Anthony J.
    MEDICINE, 2016, 95 (02)
  • [4] Loss of expression of BAP1 predicts longer survival in mesothelioma
    Farzin, Mahtab
    Toon, Christopher W.
    Clarkson, Adele
    Sioson, Loretta
    Watson, Nicole
    Andrici, Juliana
    Gill, Anthony J.
    PATHOLOGY, 2015, 47 (04) : 302 - 307
  • [5] Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma
    Farquhar, Neil
    Thornton, Sophie
    Coupland, Sarah E.
    Coulson, Judy M.
    Sacco, Joseph J.
    Krishna, Yamini
    Heimann, Heinrich
    Taktak, Azzam
    Cebulla, Colleen M.
    Abdel-Rahman, Mohamed H.
    Kalirai, Helen
    JOURNAL OF PATHOLOGY CLINICAL RESEARCH, 2018, 4 (01) : 26 - 38
  • [6] Prognostic Value of BAP1 Protein Expression in Uveal Melanoma
    Kennedy, Susan
    Owens, Sally
    Ivers, Laura
    Hegarty, Ciara
    O'Neill, Valerie
    Berenguer-Pina, Jose J.
    Horgan, Noel
    Crown, John
    Walsh, Naomi
    AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2024, 48 (03) : 329 - 336
  • [7] Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma
    Souri, Zahra
    Wierenga, Annemijn P. A.
    van Weeghel, Christiaan
    van Der Velden, Pieter A.
    Kroes, Wilma G. M.
    Luyten, Gregorius P. M.
    van Der Burg, Sjoerd H.
    Jochemsen, Aart G.
    Jager, Martine J.
    CANCERS, 2019, 11 (08)
  • [8] Expression of BAP1 and ATM proteins: Association with AJCC tumor category in uveal melanoma
    Jha, Jayanti
    Singh, Mithalesh Kumar
    Singh, Lata
    Pushker, Neelam
    Bajaj, Mandeep Singh
    Sen, Seema
    Kashyap, Seema
    ANNALS OF DIAGNOSTIC PATHOLOGY, 2020, 44
  • [9] BAP1 Immunoreactivity Correlates with Gene Expression Class in Uveal Melanoma
    See, Thonnie Rose
    Stalhammar, Gustav
    Phillips, Stephen
    Grossniklaus, Hans E.
    OCULAR ONCOLOGY AND PATHOLOGY, 2020, 6 (02) : 129 - 137
  • [10] Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing
    Kalirai, H.
    Dodson, A.
    Faqir, S.
    Damato, B. E.
    Coupland, S. E.
    BRITISH JOURNAL OF CANCER, 2014, 111 (07) : 1373 - 1380
12345