A New Synthesis of Calcium N-(5-Hydroxynicotinoyl)-L-glutamate and Its X-ray Diffraction Structure

被引：0
|
作者：
Kiselev, A. V. [1 ]
Machula, A. A. [2 ]
Efimov, S. I. [2 ]
Pashkova, E. B. [2 ]
Stovbun, S. V. [1 ]
机构：
[1] Russian Acad Sci, Semenov Inst Chem Phys, Ul Kosygina 4, Moscow 119991, Russia
[2] All Russian Res Inst Agr Radiol & Agroecol, BION, Kievskoe Shosse 109 Km, Obninsk 249032, Kaluzhskaya Obl, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 55卷 / 05期
关键词：
Ampasse; calcium N-(5-hydroxynicotinoyl)-L-glutamate; N-(5-hydroxynicotinoyl)-L-glutamic acid; 5-hydroxynicotinic acid; diethyl L-glutamate; XRD; ACID;
D O I：
10.1134/S1070428019050063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthesis of N-(5-hydroxynicotinoyl)-L-glutamic acid via a 5-hydroxynicotinic acid imidazolide intermediate has been developed. Its calcium salt (Ampasse) has been synthesized and its structure was studied by X-ray diffraction analysis. The reaction conditions for all stages of the process have been optimized and a method for the purification of the substance has been improved.
引用
收藏
页码：615 / 619
页数：5
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