Isoquinoline alkaloids from Coptis japonica stimulate the myoblast differentiation via p38 MAP-kinase and Akt signaling pathway

被引：14
作者：
Lee, Heyjin
Le Thi Tuong
Jeong, Ji Hye
Lee, Sang-Jin
Bae, Gyu-Un
Ryu, Jae-Ha [1 ]
机构：
[1] Sookmyung Womens Univ, Res Ctr Cell Fate Control, 100 Chungparo 47 Gil, Seoul 04310, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Coptis japonica; Isoquinoline alkaloid; Myoblast differentiation; MyoD; p38; MAPK; Akt; SKELETAL-MUSCLE DIFFERENTIATION; CAULIS-ET-RHIZOMA; MYOGENIC DIFFERENTIATION; MYOD; ACTIVATION; PROTEIN; MAGNOFLORINE; TRANSCRIPTION; EXPRESSION; BERBERINE;
D O I：
10.1016/j.bmcl.2017.02.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To overcome the muscle atrophy, such as cachexia and sarcopenia, we tried to find myogenic agents from medicinal plants. From myogenic extract of Coptis japonica, we purified six isoquinoline alkaloids and evaluated their effects on transactivation of myoD and MHC expression in C2C12 cells during differentiation process. Among obtained compounds, magnoflorine most efficiently enhanced the myoblast differentiation by activating the p38 MAP kinase and Akt pathway, and also increased the number of multinucleated and cylinder-shaped myotubes. These results propose that magnoflorine from Coptis japonica might be a promising lead compound for the development of anti-muscle atrophy drug. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1401 / 1404
页数：4
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