Biomarkers in Interstitial lung diseases

被引：20

作者：

Nathan, Nadia ^{[1
,2
]}

Corvol, Harriet ^{[1
,3
]}

Amselem, Serge ^{[2
,4
]}

Clement, Annick ^{[1
,2
]}

机构：

[1] Univ Paris 06, Sorbonne Univ, Hop Trousseau, AP HP,Serv Pneumol Pediat, F-75252 Paris 05, France

[2] Univ Paris 06, Sorbonne Univ, INSERM, UMR S 933, F-75252 Paris 05, France

[3] Univ Paris 06, Sorbonne Univ, INSERM, UMR S 938, F-75252 Paris 05, France

[4] Univ Paris 06, Sorbonne Univ, Hop Trousseau, AP HP,Unite Genet Mol, F-75252 Paris 05, France

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2015年 / 16卷 / 04期

关键词：

Interstitial lung diseases; Biomarkers; Idiopathic pulmonary fibrosis; IDIOPATHIC PULMONARY-FIBROSIS; SURFACTANT PROTEIN-A; MUC5B PROMOTER POLYMORPHISM; SYSTEMIC-SCLEROSIS; TGF-BETA; SERUM; CHILDREN; KL-6; PATHOGENESIS; INFLAMMATION;

D O I：

10.1016/j.prrv.2015.05.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Interstitial lung diseases (ILD)s represent a heterogeneous group of rare respiratory disorders, mostly chronic and associated with high morbidity and mortality. They are complex diseases that remain, in children, largely underdiagnosed and difficult to manage. Therefore, identification of biomarkers, which could be used for ILD diagnosis, measurements of disease severity and progression, and responsiveness to treatments, is a major challenge for clinical practice and for translational research. The present review focuses on blood biomarkers and provides an overview on the current information on molecular parameters of interest for ILD patient management. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：219 / 224

页数：6

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