Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils

被引：286

作者：

Chen, Kang ^{[1
,2
]}

Xu, Weifeng ^{[1
]}

Wilson, Melanie ^{[3
]}

He, Bing ^{[1
]}

Miller, Norman W. ^{[3
]}

Bengten, Eva ^{[3
]}

Edholm, Eva-Stina ^{[3
]}

Santini, Paul A. ^{[1
,2
]}

Rath, Poonam ^{[1
,2
]}

Chiu, April ^{[1
]}

Cattalini, Marco ^{[4
,5
]}

Litzman, Jiri ^{[6
]}

Bussel, James B. ^{[7
]}

Huang, Bihui ^{[2
,8
]}

Meini, Antonella ^{[4
,5
]}

Riesbeck, Kristian ^{[9
]}

Cunningham-Rundles, Charlotte ^{[10
]}

Plebani, Alessandro ^{[4
,5
]}

Cerutti, Andrea ^{[1
,2
]}

机构：

[1] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA

[2] Weill Cornell Grad Sch Med Sci, Grad Program Immunol & Microbial Pathogenesis, New York, NY USA

[3] Univ Mississippi, Med Ctr, Dept Microbiol, Jackson, MS 39216 USA

[4] Univ Brescia, Pediat Clin, Brescia, Italy

[5] Univ Brescia, Ist Med Mol A Nocivelli, Brescia, Italy

[6] Masaryk Univ, St Annes Univ Hosp, Dept Clin Immunol & Allergol, Brno, Czech Republic

[7] Weill Cornell Med Coll, Dept Pediat, New York, NY USA

[8] Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY USA

[9] Lund Univ, Malmo Univ Hosp, Dept Lab Med, Malmo, Sweden

[10] Mt Sinai Med Ctr, New York, NY 10029 USA

来源：

NATURE IMMUNOLOGY | 2009年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

COMMON VARIABLE IMMUNODEFICIENCY; CLASS-SWITCH RECOMBINATION; CHANNEL CATFISH; MAST-CELLS; T-CELLS; IGD; REGION; GENE; EXPRESSION; INDUCTION;

D O I：

10.1038/ni.1748

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

引用

页码：889 / U121

页数：12

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