Tolerance to Tryoanosomatics: A Threat, or a Key for Disease Elimination?

被引：38

作者：

Berthier, David ^{[1
]}

Breniere, Simone F. ^{[2
]}

Bras-Goncalves, Rachel ^{[2
]}

Lemesre, Jean-Loup ^{[2
]}

Jamonneau, Vincent ^{[3
,4
]}

Solano, Philippe ^{[5
]}

Lejon, Veerle ^{[5
]}

Thevenon, Sophie ^{[1
]}

Bucheton, Bruno ^{[5
,6
]}

机构：

[1] CIRAD, UMR INTERTRYP, F-34398 Montpellier, France

[2] IRD, UMR INTERTRYP, F-34394 Montpellier 5, France

[3] CIRDES Bobo Dioulasso, 01 BP 454, Bobo Dioulasso, Burkina Faso

[4] IPR, 01 BP 1500, Bouake 01, Cote Ivoire

[5] IRD, UMR INTERTRYP, F-34398 Montpellier 5, France

[6] Minist Sante, PNLTHA, BP 851, Conakry, Guinea

来源：

TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 02期

关键词：

HUMAN AFRICAN TRYPANOSOMIASIS; VISCERAL LEISHMANIASIS; BOVINE TRYPANOTOLERANCE; CANINE LEISHMANIASIS; GENETIC SUSCEPTIBILITY; TRANSCRIPTOME ANALYSIS; ASSOCIATION; INFECTION; CATTLE; IDENTIFICATION;

D O I：

10.1016/j.pt.2015.11.001

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

So far, research on trypanosomatid infections has been driven by 'disease by disease' approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination.

引用

页码：157 / 168

页数：12

共 70 条

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