INNOVATION Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

被引：303

作者：

Brown, Brian D. ^{[1
]}

Naldini, Luigi ^{[2
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY 10029 USA

[2] San Raffaele Telethon Inst Gene Therapy, I-20132 Milan, Italy

[3] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, I-20132 Milan, Italy

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 08期

关键词：

TRANSGENE EXPRESSION; MESSENGER-RNA; ENDOGENOUS MICRORNA; TARGET RECOGNITION; IN-VIVO; VECTORS; TISSUE; DIFFERENTIATION; INTERFERENCE; SPECIFICITY;

D O I：

10.1038/nrg2628

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

New technologies are emerging that utilize artificial microRNA (miRNA) target sites to exploit or inhibit endogenous miRNA regulation. This approach has been used to improve cell-specific targeting for gene and stem cell therapy studies and for animal transgenics, and also to reduce the toxicity of oncolytic viruses and to attenuate viral vaccines. Artificial targets have also been used to sponge or decoy miRNAs as a way to study their functions. This article considers the benefits of this approach and design considerations for future studies.

引用

页码：578 / 585

页数：8

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