Critical assessment of human antibody generation in humanized mouse models

被引：25

作者：

Villaudy, Julien ^{[1
,2
]}

Schotte, Remko ^{[1
]}

Legrand, Nicolas ^{[3
]}

Spits, Hergen ^{[1
,4
]}

机构：

[1] AIMM Therapeut, NL-1105 BA Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 BA Amsterdam, Netherlands

[3] Inst Pasteur, Ctr Francois Jacob, AXENIS, F-75015 Paris, France

[4] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 BA Amsterdam, Netherlands

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 2014年 / 410卷

关键词：

Human Immune System mouse; B cell; Antibody; Humoral immune response; FOLLICULAR DENDRITIC CELLS; HUMAN IMMUNE-SYSTEM; LYMPHOID-ORGAN DEVELOPMENT; B-CELLS; T-CELLS; VIRUS-INFECTION; MONOCLONAL-ANTIBODIES; MICE; RESPONSES; INDUCTION;

D O I：

10.1016/j.jim.2014.06.010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunodeficient mice reconstituted with human hematopoietic stem cells provide a small-animal model for the study of development and function of human hematopoietic cells in vivo. However, in the current models, the immune response, and especially the humoral response by the human immune cells is far from optimal. The B cells found in these mice exhibit an immature and abnormal phenotype correlating with a reduced capacity to produce antigen-specific affinity matured antibodies upon infection or immunization. Herein, we review the current state of knowledge of development, function and antibody production of human B cells and discuss the obstacles for the improvement of these models. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：18 / 27

页数：10

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