Experimental models of hepatotoxicity related to acute liver failure

被引：148
作者：
Maes, Michael [1 ]
Vinken, Mathieu [1 ]
Jaeschke, Hartmut [2 ]
机构：
[1] Vrije Univ Brussel, Dept In Vitro Toxicol & Dermatocosmetol, B-1090 Brussels, Belgium
[2] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Lawrence, KS 66045 USA
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 2016年 / 290卷
基金：
欧洲研究理事会; 美国国家卫生研究院;
关键词：
Hepatotoxicity; Acute liver failure; Acetaminophen; D-galactosamine; Fas ligand; Concanavalin A;
D O I：
10.1016/j.taap.2015.11.016
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Acute liver failure can be the consequence of various etiologies, with most cases arising from drug-induced hepatotoxicity in Western countries. Despite advances in this field, the management of acute liver failure continues to be one of the most challenging problems in clinical medicine. The availability of adequate experimental models is of crucial importance to provide a better understanding of this condition and to allow identification of novel drug targets, testing the efficacy of new therapeutic interventions and acting as models for assessing mechanisms of toxicity. Experimental models of hepatotoxicity related to acute liver failure rely on surgical procedures, chemical exposure or viral infection. Each of these models has a number of strengths and weaknesses. This paper specifically reviews commonly used chemical in vivo and in vitro models of hepatotoxicity associated with acute liver failure. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：86 / 97
页数：12
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