One-Pot Approach to 1,2-Disubstituted Indoles via Cu(II)-Catalyzed Coupling/Cyclization under Aerobic Conditions and Its Application for the Synthesis of Polycyclic Indoles

被引：70

作者：

Gao, Jilong ^{[1
]}

Shao, Yingying ^{[1
]}

Zhu, Jiaoyan ^{[1
]}

Zhu, Jiaqi ^{[1
]}

Mao, Hui ^{[1
]}

Wang, Xiaoxia ^{[1
]}

Lv, Xin ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Chem, Jinhua 321004, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 19期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; COUPLING REACTIONS; INTRAMOLECULAR CYCLIZATION; CATALYZED REACTIONS; MODULAR SYNTHESIS; FACILE SYNTHESIS; RING SYNTHESIS; N-ARYLATION; DERIVATIVES; INHIBITORS;

D O I：

10.1021/jo501250u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward assembly of 1,2-disubstituted indoles has been developed through a Cu(II)-catalyzed domino coupling/cyclization process. Under aerobic conditions, a wide range of 1,2-disubstituted indole derivatives were efficiently and facilely synthesized from 2-alkynylanilines and boronic acids. 2-(2-Bromoaryl)-1-aryl-1H-indoles, which were selectively generated in one pot under the Cu catalysis, afforded the indolo[1,2-f]phenanthridines via Pd-catalyzed intramolecular direct C(sp(2))-H arylation. The one-pot tandem approaches to the polycyclic indole derivatives were also successfully achieved.

引用

页码：9000 / 9008

页数：9

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