Predicting natural product value, an exploration of anti-TB drug space

被引：43

作者：

Dashti, Yousef ^{[1
]}

Grkovic, Tanja ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst Drug Discovery, Brisbane, Qld 4111, Australia

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 08期

基金：

比尔及梅琳达.盖茨基金会; 澳大利亚研究理事会;

关键词：

THIAZOLYL PEPTIDE ANTIBIOTICS; ANTIBACTERIAL ACTIVITY; BIOSYNTHETIC-ENZYMES; GUIDING PRINCIPLES; NOCARDIA SP; TUBERCULOSIS; NOCATHIACINS; FERMENTATION; INHIBITORS; MOLECULES;

D O I：

10.1039/c4np00021h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mycobacterium tuberculosis (Mtb) still remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. In last few years new drug combinations have shown promising potential to significantly shorten TB treatment times. However there are very few new chemical entities being developed to treat this global threat. From January 1990 to December 2012, 949 anti-mycobacterium natural products were reported in the literature. Here we present a perspective based on an analysis of the drug-like properties of the reported anti-mycobacterium natural products in order to assess drug potential.

引用

页码：990 / 998

页数：9

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