Dual therapeutic benefit of electroporation-mediated DNA vaccination in vivo Enhanced gene transfer and adjuvant activity

被引：26

作者：

Calvet, Christophe Y.

Andre, Franck M.

Mir, Lluis M. ^{[1
]}

机构：

[1] Univ Paris 11, Lab Vectorol & Therapeut Anticancereuses, UMR 8203, Villejuif, France

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 04期

关键词：

electropermeabilization; electric pulses; gene electrotransfer; non-viral gene therapy; immunotherapy; dendritic cell; T lymphocyte; ATP; DAMPs; DENDRITIC CELLS; IMMUNE-RESPONSE; RECRUITMENT; ANTIGEN; CANCER; ELECTROTRANSFER; BLEOMYCIN; EFFICACY; VACCINES; SIGNAL;

D O I：

10.4161/onci.28540

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to enhance DNA uptake. Here, we discuss additional immunological effects of electroporation that are key aspects for inducing immunity in response to DNA vaccines.

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