Silver-Catalyzed Tandem Hydroamination/Hydroarylation of 1-(2-Allylamino)phenyl-4-hydroxy-but-2-yn-1-ones to 1′-Allylspiro[indene-1,2′-indolin]-3′-ones

被引：48

作者：

Mothe, Srinivasa Reddy ^{[1
]}

Novianti, Maria Laurentia ^{[1
]}

Ayers, Benjamin James ^{[1
]}

Chan, Philip Wai Hong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 16期

关键词：

ENANTIOSELECTIVE SYNTHESIS; PROPARGYLIC CARBONATES; 2-SUBSTITUTED INDOLES; GENERAL-SYNTHESIS; BUILDING-BLOCKS; HYDROAMINATION; CYCLIZATION; REARRANGEMENT; ACCESS; HYDROARYLATION;

D O I：

10.1021/ol501809p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient silver triflate-catalyzed tandem hydroamination/hydroarylation cascade generating 1'-allylspiro[indene-1,2'-indolin]-3'-ones from 1-(2-allylamino)-phenyl-4-hydroxy-but-2-yn-1-ones is described. The reaction conditions are mild and general in scope and proceed to highly fiinctionalized spiro-targets in high yield. This novel class of molecule possesses both the privileged indene and indolin-3-one scaffold, which may lead to possible pharmacological applications.

引用

页码：4110 / 4113

页数：4

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