tRNA modification and cancer: potential for therapeutic prevention and intervention

被引：33
作者：
Endres, Lauren [1 ]
Fasullo, Michael [2 ]
Rose, Rebecca [3 ]
机构：
[1] State Univ New York Polytech Inst, Coll Arts & Sci, Utica, NY 13504 USA
[2] State Univ New York Polytech Inst, Coll Nanoscale Sci & Engn, Albany, NY USA
[3] NYU Langone Hlth, Metabol Core Resource Lab, New York, NY USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2019年 / 11卷 / 08期
关键词：
anticodon; cancer; codon-bias; modification; oxidative stress; tRNA; WOBBLE URIDINE MODIFICATIONS; HUMAN ALKB HOMOLOG; TRANSLATIONAL CONTROL; BREAST-CANCER; IN-VITRO; CELLULAR STRESS; AFLATOXIN B-1; SACCHAROMYCES-CEREVISIAE; OVER-EXPRESSION; GENE-EXPRESSION;
D O I：
10.4155/fmc-2018-0404
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Transfer RNAs (tRNAs) undergo extensive chemical modification within cells through the activity of tRNA methyltransferase enzymes (TRMs). Although tRNA modifications are dynamic, how they impact cell behavior after stress and during tumorigenesis is not well understood. This review discusses how tRNA modifications influence the translation of codon-biased transcripts involved in responses to oxidative stress. We further discuss emerging mechanistic details about how aberrant TRM activity in cancer cells can direct programs of codon-biased translation that drive cancer cell phenotypes. The studies reviewed here predict future preventative therapies aimed at augmenting TRM activity in individuals at risk for cancer due to exposure. They further predict that attenuating TRM-dependent translation in cancer cells may limit disease progression while leaving noncancerous cells unharmed.
引用
收藏
页码：885 / 900
页数：16
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