Can aging be 'drugged'?

被引：40

作者：

Riera, Celine E. ^{[1
,2
,3
]}

Dillin, Andrew ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

[3] Univ Calif Berkeley, Glenn Ctr Res Aging, Berkeley, CA 94720 USA

来源：

NATURE MEDICINE | 2015年 / 21卷 / 12期

关键词：

ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; GENETICALLY HETEROGENEOUS MICE; INDUCED INSULIN-RESISTANCE; DIETARY RESTRICTION; CALORIC RESTRICTION; ENERGY-EXPENDITURE; MEDIATES LONGEVITY; ADIPOSE-TISSUE; RHESUS-MONKEYS;

D O I：

10.1038/nm.4005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The engines that drive the complex process of aging are being identified by model-organism research, thereby providing potential targets and rationale for drug studies. Several studies of small molecules have already been completed in animal models with the hope of finding an elixir for aging, with a few compounds showing early promise. What lessons can we learn from drugs currently being tested, and which pitfalls can we avoid in our search for a therapeutic for aging? Finally, we must also ask whether an elixir for aging would be applicable to everyone, or whether we age differently, thus potentially shortening lifespan in some individuals.

引用

收藏

页码：1400 / 1405

页数：6

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