Can aging be 'drugged'?

被引：40

作者：

Riera, Celine E. ^{[1
,2
,3
]}

Dillin, Andrew ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

[3] Univ Calif Berkeley, Glenn Ctr Res Aging, Berkeley, CA 94720 USA

来源：

NATURE MEDICINE | 2015年 / 21卷 / 12期

关键词：

ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; GENETICALLY HETEROGENEOUS MICE; INDUCED INSULIN-RESISTANCE; DIETARY RESTRICTION; CALORIC RESTRICTION; ENERGY-EXPENDITURE; MEDIATES LONGEVITY; ADIPOSE-TISSUE; RHESUS-MONKEYS;

D O I：

10.1038/nm.4005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The engines that drive the complex process of aging are being identified by model-organism research, thereby providing potential targets and rationale for drug studies. Several studies of small molecules have already been completed in animal models with the hope of finding an elixir for aging, with a few compounds showing early promise. What lessons can we learn from drugs currently being tested, and which pitfalls can we avoid in our search for a therapeutic for aging? Finally, we must also ask whether an elixir for aging would be applicable to everyone, or whether we age differently, thus potentially shortening lifespan in some individuals.

引用

页码：1400 / 1405

页数：6

共 114 条

[1] LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys [J].

Adams, Andrew C. ;

Halstead, Carolyn A. ;

Hansen, Barbara C. ;

Irizarry, Armando R. ;

Martin, Jennifer A. ;

Myers, Sharon R. ;

Reynolds, Vincent L. ;

Smith, Holly W. ;

Wroblewski, Victor J. ;

Kharitonenkov, Alexei .

PLOS ONE, 2013, 8 (06)

[2]

Andrzejewski S, 2014, CANCER METAB, V2, DOI 10.1186/2049-3002-2-12

[3] Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice [J].

Anisimov, Vladimir N. ;

Zabezhinski, Mark A. ;

Popovich, Irina G. ;

Piskunova, Tatiana S. ;

Semenchenko, Anna V. ;

Tyndyk, Margarita L. ;

Yurova, Maria N. ;

Rosenfeld, Svetlana V. ;

Blagosklonny, Mikhail V. .

CELL CYCLE, 2011, 10 (24) :4230-4236

[4] The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C-elegans [J].

Apfeld, J ;

O'Connor, G ;

McDonagh, T ;

DiStefano, PS ;

Curtis, R .

GENES & DEVELOPMENT, 2004, 18 (24) :3004-3009

[5] SALICYLATES AS HYPOGLYCEMIC AGENTS [J].

BARON, SH .

DIABETES CARE, 1982, 5 (01) :64-71

[6] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[7] Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity [J].

Beher, Dirk ;

Wu, John ;

Cumine, Suzanne ;

Kim, Ki Won ;

Lu, Shu-Chen ;

Atangan, Larissa ;

Wang, Minghan .

CHEMICAL BIOLOGY & DRUG DESIGN, 2009, 74 (06) :619-624

[8] Monoclonal Antibodies for Migraine: Preventing Calcitonin Gene-Related Peptide Activity [J].

Bigal, Marcelo E. ;

Walter, Sarah .

CNS DRUGS, 2014, 28 (05) :389-399

[9] Extended longevity in mice lacking the insulin receptor in adipose tissue [J].

Blüher, M ;

Kahn, BB ;

Kahn, CR .

SCIENCE, 2003, 299 (5606) :572-574

[10] Decline in genomic DNA methylation through aging in a cohort of elderly subjects [J].

Bollati, Valentina ;

Schwartz, Joel ;

Wright, Robert ;

Litonjua, Augusto ;

Tarantini, Letizia ;

Suh, Helen ;

Sparrow, David ;

Vokonas, Pantel ;

Baccarelli, Andrea .

MECHANISMS OF AGEING AND DEVELOPMENT, 2009, 130 (04) :234-239

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