Ni-Catalyzed Direct Reductive Amidation via C-O Bond Cleavage

被引：131

作者：

Correa, Arkaitz ^{[1
]}

Martin, Ruben ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 20期

基金：

欧洲研究理事会;

关键词：

UNACTIVATED ALKYL BROMIDES; CROSS-COUPLING REACTIONS; ARYL HALIDES; DIRECT CARBOXYLATION; OXIDATIVE AMIDATION; BENZYL HALIDES; ISOCYANATES; ALDEHYDES; ELECTROPHILES; REACTIVITY;

D O I：

10.1021/ja5029793

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Ni-catalyzed reductive amidation of C(sp(2))-O and C(sp(3))-O electrophiles with isocyanates is described. This umpolung reaction allows for an unconventional preparation of benzamides using simple starting materials and easy-to-handle Ni catalysts.

引用

页码：7253 / 7256

页数：4

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