Plasmodium falciparum and Plasmodium vivax Genotypes and Efficacy of Intermittent Preventive Treatment in Papua New Guinea

被引：8

作者：

Barnadas, Celine ^{[1
,2
,3
]}

Senn, Nicolas ^{[1
,4
]}

Iga, Jonah ^{[1
]}

Timinao, Lincoln ^{[1
]}

Javati, Sarah ^{[1
]}

Malau, Elisheba ^{[1
,2
]}

Rarau, Patricia ^{[1
]}

Reeder, John C. ^{[5
]}

Siba, Peter ^{[1
]}

Karunajeewa, Harin ^{[2
,3
]}

Zimmerman, Peter A. ^{[6
]}

Davis, Timothy M. ^{[7
]}

Mueller, Ivo ^{[2
,3
,8
]}

机构：

[1] Papua New Guinea Inst Med Res, Vector Borne Dis Unit, Goroka, Papua N Guinea

[2] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Infect & Immun Div, Parkville, Vic 3050, Australia

[3] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia

[4] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[5] Burnet Inst, Melbourne, Vic, Australia

[6] Case Western Reserve Univ, Ctr Global Hlth & Dis, Cleveland, OH 44106 USA

[7] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia

[8] Ctr Recerca Salut Int Barcelona, Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 11期

基金：

英国医学研究理事会; 比尔及梅琳达.盖茨基金会; 澳大利亚国家健康与医学研究理事会;

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISMS; THYMIDYLATE SYNTHASE GENE; SULFADOXINE-PYRIMETHAMINE; CHLOROQUINE RESISTANCE; DRUG-RESISTANCE; MALARIA; MUTATIONS; EMERGENCE; SEQUENCE; PVMDR1;

D O I：

10.1128/AAC.03323-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and Plasmodium vivax.

引用

页码：6958 / 6961

页数：4

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