Clinical Significance of Tartrate-resistant Acid Phosphatase Type-5 Expression in Human Gastric Cancer

被引：0

作者：

Kawamura, Mikio ^{[1
]}

Tanaka, Koji ^{[1
]}

Toiyama, Yuji ^{[1
]}

Okugawa, Yoshinaga ^{[1
]}

Okigami, Masato ^{[1
]}

Yasuda, Hiromi ^{[1
]}

Saigusa, Susumu ^{[1
]}

Ohi, Masaki ^{[1
]}

Inoue, Yasuhiro ^{[1
]}

Uchida, Keiichi ^{[1
]}

Mohri, Yasuhiko ^{[1
]}

Kusunoki, Masato ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Gastrointestinal & Pediat Surg, Div Reparat Med,Inst Life Sci, Tsu, Mie 5148507, Japan

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 07期

关键词：

ACP5; gastric cancer; peritoneal dissemination; PERITONEAL CARCINOMATOSIS; METASTASIS; MARKER; FOXM1; 5B;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: The present study investigated the clinical significance of tartrate-resistant acid phosphatase type-5 (ACP5) expression in gastric cancer. Materials and Methods: In 150 specimens of gastric cancer and adjacent normal mucosa, expression of ACP5 protein and mRNA and was determined by immunohistochemical staining and quantitative real-time polymerase chain reaction, respectively. Results: Expression of ACP5 mRNA was significantly higher in cancer tissues than in adjacent normal mucosa. Elevated ACP5 mRNA was associated with lymph node metastasis and peritoneal dissemination. Logistic regression analysis revealed that elevated ACP5 expression was an independent risk factor for peritoneal dissemination and was associated with shorter survival. Immunohistochemical staining of primary carcinomas showed ACP5 to be expressed mainly in the cytoplasm. Conclusion: ACP5 is predictive of peritoneal dissemination in patients with gastric cancer, and might play a crucial role in the establishment of peritoneal dissemination.

引用

页码：3425 / 3429

页数：5

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