Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes

被引：53

作者：

Chen, Wei-Ping ^{[1
]}

Xiong, Yan ^{[1
]}

Shi, Yong-Xiang ^{[1
]}

Hu, Peng-Fei ^{[1
]}

Bao, Jia-Peng ^{[1
]}

Wu, Li-Dong ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped Surg, Hangzhou 310009, Zhejiang, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2014年 / 19卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Astaxanthin; Osteoarthritis; Matrix metalloproteinase; IN-VIVO; OSTEOARTHRITIS; SUPPLEMENTATION; CELLS;

D O I：

10.1016/j.intimp.2013.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Astaxanthin is a red carotenoid pigment which exerts multiple biological activities. However, little is known about the effects of astaxanthin on matrix metalloproteinases (MMPs) in OA. The present study investigated the effects of astaxanthin on MMPs in human chondrocytes. Human chondrocytes were pretreated with astaxanthin at 1, 10 or 50 mu M, then, cells were stimulated with IL-1 beta (10 ng/ml) for 24 h. MMP-1, MMP-3 and MMP-13 were observed. We found that astaxanthin reduced the expression of MMP-1, MMP-3 and MMP-13 as well as the phosphorylation of two mitogen-activated protein kinases (MAPK) (p38 and ERK1/2) in IL-1 beta-stimulated chondrocytes. Astaxanthin also blocked the I kappa B-alpha degradation. These results suggest that astaxanthin may be beneficial in the treatment of OA. (C) 2013 Elsevier B.V. All rights reserved.

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页码：174 / 177

页数：4

相关论文

共 19 条

[1] Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro [J].

Bau, B ;

Gebhard, PM ;

Haag, J ;

Knorr, T ;

Bartnik, E ;

Aigner, T .

ARTHRITIS AND RHEUMATISM, 2002, 46 (10) :2648-2657

[2] Molecular modeling of non-covalent binding of homochiral (3S,3′S)-astaxanthin to matrix metalloproteinase-13 (MMP-13) [J].

Bikadi, Zsolt ;

Hazai, Eszter ;

Zsila, Ferenc ;

Lockwood, Samuel F. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (16) :5451-5458

[3] Matrix metalloproteinases: Role in arthritis [J].

Burrage, PS ;

Mix, KS ;

Brinckerhoff, CE .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2006, 11 :529-543

[4] Antioxidative and Anti-Inflammatory Neuroprotective Effects of Astaxanthin and Canthaxanthin in Nerve Growth Factor Differentiated PC12 Cells [J].

Chan, Kung-chi ;

Mong, Mei-chin ;

Yin, Mei-chin .

JOURNAL OF FOOD SCIENCE, 2009, 74 (07) :H225-H231

[5] Morin inhibits interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes [J].

Chen, Wei-Ping ;

Wang, Yu-Lu ;

Tang, Jing-Li ;

Hu, Peng-Fei ;

Bao, Jia-Peng ;

Wu, Li-Dong .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2012, 12 (02) :447-452

[6] Effects of Astaxanthin on the Production of NO and the Expression of COX-2 and iNOS in LPS-Stimulated BV2 Microglial Cells [J].

Choi, Seok-Keun ;

Park, Young-Sam ;

Choi, Dong-Kug ;

Chang, Hyo-Ihl .

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 18 (12) :1990-1996

[7]

Djordjevic B, 2012, J SPORT MED PHYS FIT, V52, P382

[8] Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants [J].

Fosang, AJ ;

Last, K ;

Stanton, H ;

Weeks, DB ;

Campbell, IK ;

Hardingham, TE ;

Hembry, RM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (42) :33027-33037

[9] TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population [J].

Han, Lin ;

Song, Joo Hyoun ;

Yoon, Jung Hwan ;

Park, Yong Gyu ;

Lee, Suk Woo ;

Choi, Yoo Jin ;

Nam, Suk Woo ;

Lee, Jung Young ;

Park, Won Sang .

KOREAN JOURNAL OF PATHOLOGY, 2012, 46 (01) :30-37

[10] Astaxanthin Inhibits H2O2-Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways [J].

Kim, Jeong-Hwan ;

Choi, Woobong ;

Lee, Jong-Hwan ;

Jeon, Sung-Jong ;

Choi, Yung-Hyun ;

Kim, Byung-Woo ;

Chang, Hyo-Ihl ;

Nam, Soo-Wan .

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2009, 19 (11) :1355-1363