Multiscale modeling of blood flow: from single cells to blood rheology

被引：190

作者：

Fedosov, Dmitry A. ^{[1
,2
]}

Noguchi, Hiroshi ^{[3
]}

Gompper, Gerhard ^{[1
,2
]}

机构：

[1] Forschungszentrum Julich, Inst Complex Syst, D-52425 Julich, Germany

[2] Forschungszentrum Julich, Inst Adv Simulat, D-52425 Julich, Germany

[3] Univ Tokyo, Inst Solid State Phys, Chiba 2778581, Japan

来源：

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY | 2014年 / 13卷 / 02期

关键词：

Red blood cell; Dissipative particle dynamics; Multiparticle collision dynamics; Blood rheology; Shear-thinning; Capillary flow; Microvessels; Discocyte; parachute; and slipper shapes; MULTIPARTICLE COLLISION DYNAMICS; LATTICE-BOLTZMANN; PLASMODIUM-FALCIPARUM; LEUKOCYTE MARGINATION; FREE LAYER; MESOSCALE SIMULATION; COMPUTATIONAL MODEL; ADHESIVE DYNAMICS; PLASMA-PROTEINS; FLUID VESICLES;

D O I：

10.1007/s10237-013-0497-9

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Mesoscale simulations of blood flow, where the red blood cells are described as deformable closed shells with a membrane characterized by bending rigidity and stretching elasticity, have made much progress in recent years to predict the flow behavior of blood cells and other components in various flows. To numerically investigate blood flow and blood-related processes in complex geometries, a highly efficient simulation technique for the plasma and solutes is essential. In this review, we focus on the behavior of single and several cells in shear and microcapillary flows, the shear-thinning behavior of blood and its relation to the blood cell structure and interactions, margination of white blood cells and platelets, and modeling hematologic diseases and disorders. Comparisons of the simulation predictions with existing experimental results are made whenever possible, and generally very satisfactory agreement is obtained.

引用

页码：239 / 258

页数：20

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