Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging

被引：71

作者：

Cui, Xianjin ^{[1
]}

Belo, Salome ^{[1
]}

Krueger, Dirk ^{[1
]}

Yan, Yong ^{[2
]}

de Rosales, Rafael T. M. ^{[1
]}

Jauregui-Osoro, Maite ^{[1
]}

Ye, Haitao ^{[3
]}

Su, Shi ^{[3
]}

Mathe, Domokos ^{[4
]}

Kovacs, Noemi ^{[4
]}

Horvath, Ildiko ^{[4
]}

Semjeni, Mariann ^{[4
]}

Sunassee, Kavitha ^{[1
]}

Szigeti, Krisztian ^{[6
]}

Green, Mark A. ^{[1
,5
]}

Blower, Philip J. ^{[1
,7
]}

机构：

[1] Kings Coll London, St Thomas Hosp, Div Imaging Sci & Biomed Engn, London SE1 7EH, England

[2] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[3] Aston Univ, Sch Engn & Appl Sci, Birmingham B4 7ET, W Midlands, England

[4] CROmed Ltd, H-1047 Budapest, Hungary

[5] Kings Coll London, Dept Phys, London WC2R 2LS, England

[6] Semmelweis Univ, Dept Biophys & Radiat Biol, Nanobiotechnol & Vivo Imaging Ctr, H-1094 Budapest, Hungary

[7] Kings Coll London, Div Chem, London SE1 1DB, England

来源：

BIOMATERIALS | 2014年 / 35卷 / 22期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

Magnetic nanoparticles; PET; MR; Aluminium hydroxide; Dual-modal; F-18; IRON-OXIDE NANOPARTICLES; MAGNETIC NANOPARTICLES;

D O I：

10.1016/j.biomaterials.2014.04.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Magnetic nanoparticles (NPs) MnFe2O4 and Fe3O4 were stabilised by depositing an Al(OH)(3) layer via a hydrolysis process. The particles displayed excellent colloidal stability in water and a high affinity to [F-18]-fluoride and bisphosphonate groups. A high radiolabeling efficiency, 97% for F-18-fluoride and 100% for Cu-64-bisphosphonate conjugate, was achieved by simply incubating NPs with radioactivity solution at room temperature for 5 min. The properties of particles were strongly dependant on the thickness and hardness of the Al(OH)(3) layer which could in turn be controlled by the hydrolysis method. The application of these Al(OH)(3) coated magnetic NPs in molecular imaging has been further explored. The results demonstrated that these NPs are potential candidates as dual modal probes for MR and PET. In vivo PET imaging showed a slow release of F-18 from NPs, but no sign of efflux of Cu-64. (C) 2014 The Authors. Published by Elsevier Ltd.

引用

页码：5840 / 5846

页数：7

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