Synthetic strategies to prepare 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines

被引：14
作者：
Montalbetti, Christian A. G. N.
Coulter, Thomas S.
Uddin, Muhammed K.
Reigniera, Serge G.
Magaraci, Filippo
Granas, Charlotta
Krog-Jensen, Christian
Felding, Jakob
机构：
[1] Evotec, Abingdon OX14 4RX, Oxon, England
[2] BioImage AS, DK-2860 Soborg, Denmark
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 33期
关键词：
triazine; Sonogashira; Suzuki; nucleophilic substitution; PI3 kinase pathway inhibitors; FOXO1; translocation;
D O I：
10.1016/j.tetlet.2006.06.045
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed synthetic protocols to generate 2-alkyl, 2-aryl and 2-acetylenyl substituted 4,6-diamino-1,3,5-triazines from the corresponding 2-chloro compound. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5973 / 5975
页数：3
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