Changes in Early Serum Metal Ion Levels and Impact on Liver, Kidney, and Immune Markers Following Metal-on-Metal Total Hip Arthroplasty

被引：11

作者：

Chen, Zhefeng ^{[1
]}

Wang, Zhen ^{[1
]}

Wang, Qing ^{[1
]}

Cui, Weiding ^{[1
]}

Liu, Feng ^{[1
]}

Fan, Weimin ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanjing 210029, Jiangsu, Peoples R China

来源：

JOURNAL OF ARTHROPLASTY | 2014年 / 29卷 / 03期

关键词：

metal-on-metal; metal-on-polyethylene; metal ion; immunity; hip arthroplasty; DIAMETER TOTAL HIP; LONG-TERM; JOHN CHARNLEY; REPLACEMENT; CHROMIUM; COBALT; RELEASE; WEAR; BEARINGS; IMPLANTS;

D O I：

10.1016/j.arth.2013.07.031

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We retrospectively studied 32 consecutive patients (32 hips) who underwent THA with a Durom large-head, MOM articulation between January 2008 and December 2010. Of the patients who underwent THA using a Trilogy metal on polyethylene prosthesis during the same period, 32 were chosen to form the Trilogy group. 32 volunteers were chosen to form the control group. At the last follow-up, serum metal ion levels, liver and kidney function and host immunologic immune responses were evaluated. The mean Co and Cr levels in the Durom group were 4.33- and 1.95-fold higher than those in the Trilogy group. CD3 +, CD4 + and CD8 + cell levels in the Durom group were significantly decreased. The INF-gamma level in the Durom group was significantly higher than that in the Trilogy and control groups. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：612 / 616

页数：5

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