Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain

被引：121

作者：

Ozarowski, Marcin ^{[1
,2
]}

Mikolajczak, Przemyslaw L. ^{[1
,3
]}

Bogacz, Anna ^{[1
,5
]}

Gryszczynska, Agnieszka ^{[1
]}

Kujawska, Malgorzata ^{[4
]}

Jodynis-Liebert, Jadwiga ^{[4
]}

Piasecka, Anna ^{[7
]}

Napieczynska, Hanna ^{[3
]}

Szulc, Michal ^{[3
]}

Kujawski, Radoslaw ^{[1
]}

Bartkowiak-Wieczorek, Joanna ^{[1
,5
]}

Cichocka, Joanna ^{[1
]}

Bobkiewicz-Kozlowska, Teresa ^{[3
]}

Czerny, Boguslaw ^{[1
,6
]}

Mrozikiewicz, Przemyslaw M. ^{[1
,5
]}

机构：

[1] Inst Nat Fibres & Med Plants, PL-60630 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Pharmaceut Bot & Plant Biotechnol, PL-61861 Poznan, Poland

[3] Poznan Univ Med Sci, Dept Pharmacol, PL-608060 Poznan, Poland

[4] Poznan Univ Med Sci, Dept Toxicol, PL-60631 Poznan, Poland

[5] Poznan Univ Med Sci, Dept Clin Pharm & Biopharm, Lab Expt Pharmacogenet, PL-61781 Poznan, Poland

[6] Pomeranian Med Univ, Dept Gen Pharmacol & Pharmacoecon, PL-70204 Szczecin, Poland

[7] Polish Acad Sci, Inst Plant Genet, Metabol Team, Dept Pathogen Genet & Plant Resistance, PL-60479 Poznan, Poland

来源：

FITOTERAPIA | 2013年 / 91卷

关键词：

Rosemary; Memory; Acetylcholinesterase; Butyrylcholinesterase; Rat; ALZHEIMERS-DISEASE; SECONDARY METABOLITES; MEXICAN LUPINE; HUPERZINE; PHARMACOLOGY; DYSFUNCTION; RETENTION; LAMIACEAE; MODEL; MICE;

D O I：

10.1016/j.fitote.2013.09.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rosmarinus officinalis L leaf as part of a diet and medication can be a valuable proposal for the prevention and treatment of dementia. The aim of the study was to assess the effects of subchronic (28-fold) administration of a plant extract (RE) (200 mg/kg, p.o.) on behavioral and cognitive responses of rats linked with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity and their mRNA expression level in the hippocampus and frontal cortex. The passive avoidance test results showed that RE improved long-term memory in scopolamine-induced rats. The extract inhibited the AChE activity and showed a stimulatory effect on BuChE in both parts of rat brain. Moreover, RE produced a lower mRNA BuChE expression in the cortex and simultaneously an increase in the hippocampus. The study suggests that RE led to improved long-term memory in rats, which can be partially explained by its inhibition of AChE activity in rat brain. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：261 / 271

页数：11

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