Multi-Component Hydrogen-Bonding Assembly of a Pharmaceutical Agent Pamoic Acid with Piperazine or 4,4′-Bipyridyl: A Channel Hydrated Salt with Multiple-Helical Motifs vs a Bimolecular Cocrystal

被引：84

作者：

Du, Miao ^{[1
]}

Zhang, Zhi-Hui ^{[1
]}

Guo, Wei ^{[1
]}

Fu, Xiao-Juan ^{[1
]}

机构：

[1] Tianjin Normal Univ, Coll Chem & Life Sci, Tianjin Key Lab Struct & Performance Funct Mol, Tianjin 300387, Peoples R China

来源：

CRYSTAL GROWTH & DESIGN | 2009年 / 9卷 / 04期

基金：

中国国家自然科学基金;

关键词：

SUPRAMOLECULAR ASSEMBLIES; BUILDING-BLOCKS; STACKING; RECOGNITION; COMPLEXES; CRYSTALS; POLYMERS; TWIST;

D O I：

10.1021/cg801393a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Assembly of pamoic acid (H(2)PA) with piperazine (PIPO) or 4,4'-bipyridyl (BIPY) results in two distinct supramolecular complexes [(PA)center dot(H2PIPO)]center dot 3H(2)O (1) and [(H(2)PA)center dot(BIPY)] (2). The former displays triple-helix host arrays via charge-assisted N+-H center dot center dot center dot O- interactions with the inclusion of helical water chains, whereas the latter represents the first cocrystal of pamoic acid sustaining by the familiar carboxyl-pyridyl H-bonding synthons. Notably, the structure of 1 can be dehydrated/rehydrated with retention of crystallinity.

引用

页码：1655 / 1657

页数：3