The Role of the Transcription Factor KLF2 in Vascular Development and Disease

被引：85

作者：

Novodvorsky, Peter ^{[1
,2
]}

Chico, Timothy J. A. ^{[1
,2
]}

机构：

[1] Univ Sheffield, MRC Ctr Dev & Biomed Genet, Sheffield, S Yorkshire, England

[2] Univ Sheffield, Dept Cardiovasc Sci, Sheffield, S Yorkshire, England

来源：

GENETICS OF CARDIOVASCULAR DISEASE | 2014年 / 124卷

基金：

英国医学研究理事会;

关键词：

KRUPPEL-LIKE FACTOR-2; FLUID SHEAR-STRESS; ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; THIOREDOXIN-INTERACTING PROTEIN; LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; BLOOD-BRAIN-BARRIER; REGULATORY T-CELLS;

D O I：

10.1016/B978-0-12-386930-2.00007-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of processes during development and disease such as endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation. In this review, we summarize the current understanding about KLF2 with a focus on its effects on vascular biology.

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页码：155 / 188

页数：34

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