Cerebrospinal fluid biomarker for Parkinson's disease: An overview

被引：32
作者：
Maass, Fabian [1 ]
Schulz, Isabel [2 ]
Lingor, Paul [4 ]
Mollenhauer, Brit [1 ,3 ]
Baehr, Mathias [1 ]
机构：
[1] Univ Med Ctr, Dept Neurol, Robert Koch Str 40, D-37075 Gottingen, Germany
[2] Univ Southampton, Fac Med, 12 Univ Rd, Southampton SO17 1BJ, Hants, England
[3] Paracelsus Elena Klin, Klin Str 16, D-24128 Kassel, Germany
[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, Ismaninger Str 22, D-81675 Munich, Germany
来源：
MOLECULAR AND CELLULAR NEUROSCIENCE | 2019年 / 97卷
关键词：
Parkinson's disease; Biomarker; CSF; ALPHA-SYNUCLEIN; CSF BIOMARKERS; BIOLOGICAL-FLUIDS; AMYLOID-BETA; T-TAU; PROGRESSION; NEURODEGENERATION; DIAGNOSIS; MARKERS; PROTEIN;
D O I：
10.1016/j.mcn.2018.12.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In Parkinson's disease (PD), there is a wide field of recent and ongoing search for useful biomarkers for early and differential diagnosis, disease monitoring or subtype characterization. Up to now, no biofluid biomarker has entered the daily clinical routine. Cerebrospinal fluid (CSF) is often used as a source for biomarker development in different neurological disorders because it reflects changes in central-nervous system homeostasis. This review article gives an overview about different biomarker approaches in PD, mainly focusing on CSF analyses. Current state and future perspectives regarding classical protein markers like alpha-synuclein, but also different "omics" techniques are described. In conclusion, technical advancements in the field already yielded promising results, but further multicenter trials with well-defined cohorts, standardized protocols and integrated data analysis of different modalities are needed before successful translation into routine clinical application.
引用
收藏
页码：60 / 66
页数：7
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