Preventing pregnancy loss

被引:3
作者
Connors, Jean M. [1 ,2 ]
机构
[1] Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Cambridge, MA 02138 USA
关键词
MOLECULAR-WEIGHT HEPARIN; RANDOMIZED CONTROLLED-TRIAL; ASPIRIN PLUS HEPARIN; FACTOR-V-LEIDEN; WOMEN; COMPLICATIONS; THROMBOPHILIA;
D O I
10.1182/blood-2013-11-538314
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In this issue of Blood, 2 articles by The Nîmes Obstetricians and Hematologists-Antiphospholipid Syndrome (NOH-APS) Study Group give us new information about the effects of low-molecular-weight heparin (LMWH) on pregnancy complications in women with prior pregnancy loss and either purely obstetric antiphospholipid syndrome (APS) or inherited thrombophilia. The results better define women at risk, suggest a role for LMWH, and confirm the need for further investigation. © 2014 by The American Society of Hematology.
引用
收藏
页码:308 / 310
页数:5
相关论文
共 11 条
[1]   Heparin rescues factor V Leiden-associated placental failure independent of anticoagulation in a murine high-risk pregnancy model [J].
An, Jianzhong ;
Waitara, Magarya S. ;
Bordas, Michelle ;
Arumugam, Vidhyalakshmi ;
Hoffmann, Raymond G. ;
Petrich, Brian G. ;
Sinha, Uma ;
North, Paula E. ;
Sood, Rashmi .
BLOOD, 2013, 121 (11) :2127-2134
[2]   VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [J].
Bates, Shannon M. ;
Greer, Ian A. ;
Middeldorp, Saskia ;
Veenstra, David L. ;
Prabulos, Anne-Marie ;
Vandvik, Per Olav .
CHEST, 2012, 141 (02) :E691S-E736S
[3]   Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH-APS observational study [J].
Bouvier, Sylvie ;
Cochery-Nouvellon, Eva ;
Lavigne-Lissalde, Geraldine ;
Mercier, Erick ;
Marchetti, Tess ;
Balducchi, Jean-Pierre ;
Mares, Pierre ;
Gris, Jean-Christophe .
BLOOD, 2014, 123 (03) :404-413
[4]   Comparative incidence of pregnancy outcomes in thrombophilia-positive women from the NOH-APS observational study [J].
Bouvier, Sylvie ;
Cochery-Nouvellon, Eva ;
Lavigne-Lissalde, Geraldine ;
Mercier, Erick ;
Fabbro-Peray, Pascale ;
Balducchi, Jean-Pierre ;
Mares, Pierre ;
Gris, Jean-Christophe .
BLOOD, 2014, 123 (03) :414-421
[5]   SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage [J].
Clark, Peter ;
Walker, Isobel D. ;
Langhorne, Peter ;
Crichton, Lena ;
Thomson, Andrew ;
Greaves, Mike ;
Whyte, Sonia ;
Greer, Ian A. .
BLOOD, 2010, 115 (21) :4162-4167
[6]   Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT [J].
De Vries, J. I. P. ;
Van Pampus, M. G. ;
Hague, W. M. ;
Bezemer, P. D. ;
Joosten, J. H. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2012, 10 (01) :64-72
[7]   Antiphospholipid syndrome in pregnancy: A randomized, controlled trial of treatment [J].
Farquharson, RG ;
Quenby, S ;
Greaves, M .
OBSTETRICS AND GYNECOLOGY, 2002, 100 (03) :408-413
[8]   Aspirin plus Heparin or Aspirin Alone in Women with Recurrent Miscarriage [J].
Kaandorp, Stef P. ;
Goddijn, Mariette ;
van der Post, Joris A. M. ;
Hutten, Barbara A. ;
Verhoeve, Harold R. ;
Hamulyak, Karly ;
Mol, Ben Willem ;
Folkeringa, Nienke ;
Nahuis, Marleen ;
Papatsonis, Dimitri N. M. ;
Buller, Harry R. ;
van der Veen, Fulco ;
Middeldorp, Saskia .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (17) :1586-1596
[9]   Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies) [J].
Rai, R ;
Cohen, H ;
Dave, M ;
Regan, L .
BRITISH MEDICAL JOURNAL, 1997, 314 (7076) :253-257
[10]   Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial [J].
Rey, E. ;
Garneau, P. ;
David, M. ;
Gauthier, R. ;
Leduc, L. ;
Michon, N. ;
Morin, F. ;
Demers, C. ;
Kahn, S. R. ;
Magee, L. A. ;
Rodger, M. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 (01) :58-64