Future Antibacterial Strategies: From Basic Concepts to Clinical Challenges

被引：91
作者：
Cattoir, Vincent [1 ,2 ,3 ]
Feldan, Brice [1 ]
机构：
[1] Univ Rennes 1, UMR S 1230, INSERM, Bacterial Regulatory RNAs & Med, Rennes, France
[2] Rennes Univ Hosp, Dept Clin Microbiol, Rennes, France
[3] Natl Reference Ctr Antimicrobial Resistance, Rennes, France
来源：
JOURNAL OF INFECTIOUS DISEASES | 2019年 / 220卷 / 03期
关键词：
antimicrobial resistance; multidrug resistance; antibacterials; therapeutic alternatives; ANTIBIOTIC-RESISTANCE; ALTERNATIVES; VACCINATION; INHIBITORS; DISCOVERY; PATHOGENS; PEPTIDES; STATE; RNAS;
D O I：
10.1093/infdis/jiz134
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review presents potential benefits and limitations of innovative strategies that are currently investigated for the discovery of novel antibacterial agents to prevent or treat infections caused by multidrug-resistant organisms.
引用
收藏
页码：350 / 360
页数：11
相关论文
共 63 条
[1]   Editorial: Phage Therapy: Past, Presentand Future [J].
Abedon, Stephen T. ;
Garcia, Pilar ;
Mullany, Peter ;
Aminov, Rustam .
FRONTIERS IN MICROBIOLOGY, 2017, 8
[2]   Phage Therapy in the Postantibiotic Era [J].
Altamirano, Fernando L. Gordillo ;
Barr, Jeremy J. .
CLINICAL MICROBIOLOGY REVIEWS, 2019, 32 (02)
[3]   Related actions of probiotics and antibiotics on gut microbiota and weight modification [J].
Angelakis, Emmanoui ;
Merhej, Vicky ;
Raoult, Didier .
LANCET INFECTIOUS DISEASES, 2013, 13 (10) :889-899
[4]  
[Anonymous], 2016, COLD SPRING HARB PER
[5]   Vaccination to reduce antimicrobial resistance [J].
Atkins, Katherine E. ;
Flasche, Stefan .
LANCET GLOBAL HEALTH, 2018, 6 (03) :E252-E252
[6]   Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules [J].
Banik, Jacob J. ;
Brady, Sean F. .
CURRENT OPINION IN MICROBIOLOGY, 2010, 13 (05) :603-609
[7]   Challenges and Solutions for Clinical Development of New Antibacterial Agents: Results of a Survey among Pharmaceutical Industry Professionals [J].
Bettiol, Esther ;
Wetherington, Jeffrey D. ;
Schmitt, Nicola ;
Harbarth, Stephan .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (07) :3695-3699
[8]   Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials [J].
Bikard, David ;
Euler, Chad W. ;
Jiang, Wenyan ;
Nussenzweig, Philip M. ;
Goldberg, Gregory W. ;
Duportet, Xavier ;
Fischetti, Vincent A. ;
Marraffini, Luciano A. .
NATURE BIOTECHNOLOGY, 2014, 32 (11) :1146-1150
[9]   Conjugation Inhibitors and Their Potential Use to Prevent Dissemination of Antibiotic Resistance Genes in Bacteria [J].
Cabezon, Elena ;
de la Cruz, Fernando ;
Arechaga, Ignacio .
FRONTIERS IN MICROBIOLOGY, 2017, 8
[10]   Bacteriocins and their position in the next wave of conventional antibiotics [J].
Cavera, Veronica L. ;
Arthur, Timothy D. ;
Kashtanov, Dimitri ;
Chikindas, Michael L. .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2015, 46 (05) :494-501
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