Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells

被引：62
作者：
Lian, Song [1 ]
Su, Hua [2 ]
Zhao, Bao-Xiang [1 ]
Liu, Wei-Yong [1 ]
Zheng, Liang-Wen [1 ]
Miao, Jun-Ying [2 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Inst Organ Chem, Jinan 250100, Peoples R China
[2] Shandong Univ, Sch Life Sci, Inst Dev Biol, Jinan 250100, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 20期
基金：
中国国家自然科学基金;
关键词：
Pyrazole; N-Glycoside; Synthesis; Growth inhibitory; Autophagy; PRELIMINARY BIOLOGICAL EVALUATION; POTENTIAL AGENTS; PYRAZIN-4(5H)-ONE DERIVATIVES; HETEROCYCLIC-DERIVATIVES; HYDRAZONE DERIVATIVES; ANTITUMOR-ACTIVITY; C-NUCLEOSIDES; PYRAZOLE; ASSAY; BIOACTIVITY;
D O I：
10.1016/j.bmc.2009.09.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carbohydrazide N-beta-glycoside derivatives was synthesized by the reaction of substituted 1H-pyrazole-5-carbohydrazide with D-sugar and the effects of all the compounds on A549 cell growth were investigated. The results showed that all compounds had inhibitory effects on the growth of A549 lung cancer cells and compound 3d possessed the highest growth inhibitory effect and induced autophagy of A549 lung cancer cells. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7085 / 7092
页数：8
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