Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis (Review)

被引：31
|
作者：
Zhao, Zhiwei [1 ]
Wang, Shichao [1 ,2 ]
Lin, Yingbo [3 ]
Miao, Yali [4 ]
Zeng, Ye [1 ]
Nie, Yongmei [2 ]
Guo, Peng [1 ]
Jiang, Guangyao [5 ]
Wu, Jiang [1 ,2 ]
机构：
[1] Sichuan Univ, West China Med Ctr, 17 Sect 3 Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China
[2] Xinjiang Med Univ, Sch Basic Med, Urumqi 830011, Xinjiang, Peoples R China
[3] Karolinska Inst, Canc Ctr Karolinska, Dept Oncol & Pathol, SE-17176 Stockholm, Sweden
[4] Sichuan Univ, West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China
[5] Sichuan Univ, West China Hosp 4, Outpatient Bldg,18 3rd Sect,Renmin Nanlu Rd, Chengdu 610041, Sichuan, Peoples R China
来源：
ONCOLOGY LETTERS | 2017年 / 13卷 / 06期
基金：
中国国家自然科学基金;
关键词：
interleukin-8; C-X-C motif chemokine receptor 1; C-X-C motif chemokine receptor 2; epithelial-mesenchymal transition; metastasis; prognosis; ENDOTHELIAL GROWTH-FACTOR; CELLS IN-VITRO; OVARIAN-CANCER; TUMOR ANGIOGENESIS; INTERLEUKIN-8; EXPRESSION; COLORECTAL-CANCER; UP-REGULATION; BETA-CATENIN; E-CADHERIN; IL-8;
D O I：
10.3892/ol.2017.6034
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Epithelial-mesenchymal transition (EMT) is a biological process that is associated with cancer metastasis and invasion. In cancer, EMT promotes cell motility, invasion and distant metastasis. Interleukin (IL)-8 is highly expressed in tumors and may induce EMT. The IL-8/IL-8R axis has a vital role in EMT in carcinoma, which is regulated by several signaling pathways, including the transforming growth factor beta-spleen associated tyrosine kinase/Src-AKT/extracellular signal-regulated kinase, p38/Jun N-terminal kinase-acti-vating transcription factor-2, phosphoinositide 3-kinase/AKT, nuclear factor-kappa B and Wnt signaling pathways. Blocking the IL-8/IL-8R signaling pathway may be a novel strategy to reduce metastasis and improve patient survival rates. This review will cover IL-8-IL-8R signaling pathway in tumor epithelial-mesenchymal transition.
引用
收藏
页码：4577 / 4584
页数：8
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