International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study

被引：113

作者：

Fox, Philip R. ^{[1
,2
]}

Keene, Bruce W. ^{[3
]}

Lamb, Kenneth ^{[4
]}

Schober, Karsten A. ^{[5
]}

Chetboul, Valerie ^{[6
]}

Fuentes, Virginia Luis ^{[7
]}

Wess, Gerhard ^{[8
]}

Payne, Jessie Rose ^{[7
]}

Hogan, Daniel F. ^{[9
]}

Motsinger-Reif, Alison ^{[10
]}

Haggstrom, Jens ^{[11
]}

Trehiou-Sechi, Emilie ^{[12
]}

Fine-Ferreira, Deborah M. ^{[13
]}

Nakamura, Reid K. ^{[14
]}

Lee, Pamela M. ^{[1
,2
]}

Singh, Manreet K. ^{[15
]}

Ware, Wendy A. ^{[16
]}

Abbott, Jonathan A. ^{[17
]}

Culshaw, Geoffrey ^{[18
]}

Riesen, Sabine ^{[19
]}

Borgarelli, Michele ^{[20
]}

Lesser, Michael B. ^{[21
]}

Van Israel, Nicole ^{[22
]}

Cote, Etienne ^{[23
]}

Rush, John E. ^{[24
]}

Bulmer, Barret ^{[25
]}

Santilli, Roberto A. ^{[26
]}

Vollmar, Andrea C. ^{[27
,28
]}

Bossbaly, Maribeth J. ^{[29
]}

Quick, Nadine ^{[30
]}

Bussadori, Claudio ^{[31
]}

Bright, Janice M. ^{[32
]}

Estrada, Amara H. ^{[33
]}

Ohad, Dan G. ^{[34
]}

Fernandez-Del Palacio, Maria Josefa ^{[35
]}

Brayley, Jenifer Lunney ^{[36
]}

Schwartz, Denise S. ^{[37
]}

Bove, Christina M. ^{[38
]}

Gordon, Sonya G. ^{[39
]}

Jung, Seung Woo ^{[40
]}

Brambilla, Paola ^{[41
]}

Moise, N. Sydney ^{[42
]}

Stauthammer, Christopher D. ^{[43
]}

Stepien, Rebecca L. ^{[44
]}

Quintavalla, Cecilia ^{[45
]}

Amberger, Christophe ^{[46
]}

Manczur, Ferenc ^{[47
]}

Hung, Yong-Wei ^{[48
]}

Lobetti, Remo ^{[49
]}

De Swarte, Marie ^{[50
]}

机构：

[1] Anim Med Ctr, Dept Cardiol, New York, NY USA

[2] Anim Med Ctr, Caspary Res Inst, New York, NY USA

[3] North Carolina State Univ, Dept Clin Sci, Raleigh, NC USA

[4] Lamb Consulting, Minneapolis, MN USA

[5] Ohio State Univ, Dept Vet Clin Sci, Columbus, OH 43210 USA

[6] Ecole Natl Vet Alfort, Alfort Cardiol Unit, Maisons Alfort, France

[7] Royal Vet Coll, Dept Vet Clin Sci & Serv, Hatfield, Herts, England

[8] Ludwig Maximilians Univ Munchen, Clin Small Anim Med, Munich, Germany

[9] Purdue Univ, Dept Vet Clin Sci, W Lafayette, IN 47907 USA

[10] North Carolina State Univ, Dept Stat, Raleigh, NC USA

[11] Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden

[12] Ecole Natl Vet Alfort, Alfort Cardiol Unit, Maisons Alfort, France

[13] Univ Missouri, Dept Vet Med & Surg, Columbia, MO USA

[14] Adv Vet Care Ctr, Lawndale, CA USA

[15] Univ Calif Davis, William R Pritchard Vet Med Teaching Hosp, Davis, CA 95616 USA

[16] Iowa State Univ, Dept Vet Clin Sci, Ames, IA USA

[17] Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA USA

[18] Univ Edinburgh, Royal Dick SVS Hosp Small Anim, Roslin, Midlothian, Scotland

[19] Univ Vet Med, Dept Compan Anim & Horses, Vienna, Austria

[20] Kansas State Univ, Dept Clin Sci, Manhattan, KS USA

[21] Adv Vet Care Ctr, Lawndale, CA USA

[22] Anim CardioPulm Consultancy, Masta, Stavelot, Belgium

[23] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Compan Anim, Charlottetown, PE, Canada

[24] Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA

[25] Tufts Vet Emergency Treatment & Specialties, Walpole, MA USA

[26] Clin Vet Malpensa, Dept Cardiol, Varese, Italy

[27] Fachtieraerztin Kleintiere, Wissen, Germany

[28] Fachtieraerztin Kleintiere, Bonn, Germany

[29] Vet Specialty & Emergency Ctr, Levittown, PA USA

[30] Ludwig Maximilians Univ Munchen, Clin Small Anim Med, Munich, Germany

[31] Clin Vet Gran Sasso, Dept Cardiol, Milan, Italy

[32] Colorado State Univ, Dept Clin Sci, Ft Collins, CO 80523 USA

[33] Univ Florida, Dept Small Anim Clin Sci, Gainesville, FL USA

[34] Koret Sch Vet Med, Dept Clin Sci, Rehovot, Israel

[35] Univ Murcia, Dept Med & Cirug Anim, Murcia, Spain

[36] Vet Med Specialists Houston, Houston, TX USA

[37] Univ Sao Paulo, Dept Internal Med, Sao Paulo, Brazil

[38] Univ Guelph, Dept Clin Studies, Guelph, ON, Canada

[39] Texas A&M Univ, Dept Small Anim Clin Sci, College Stn, TX USA

[40] Univ Calif Davis, William R Pritchard Vet Med Teaching Hosp, Davis, CA 95616 USA

[41] Univ Milan, Dept Vet Med, Milan, Italy

[42] Cornell Univ, Dept Clin Sci, Ithaca, NY USA

[43] Univ Minnesota, Dept Vet Clin Sci, St Paul, MN 55108 USA

[44] Univ Wisconsin, Sch Vet Med, Dept Med Sci, Madison, WI 53706 USA

[45] Univ Parma, Dept Vet Sci, Parma, Italy

[46] Cabinet Vet & Ctr Imagerie, Geneva, Switzerland

[47] Univ Vet Med, Dept Internal Med, Budapest, Hungary

[48] Cardiospecial Vet Hosp, Taipei, Taiwan

[49] Bryanston Vet Hosp, Bryanston, South Africa

[50] Univ Coll Dublin, Univ Coll Dublin Vet Hosp, Dublin, Ireland

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 2018年 / 32卷 / 03期

关键词：

arterial thromboembolism; asymptomatic; congestive heart failure; epidemiology; incidence; outcome; survival; OUTFLOW TRACT OBSTRUCTION; MAINE COON CATS; PROTEIN-C GENE; HUMAN-DISEASE; ANIMAL-MODEL; ARTERIAL THROMBOEMBOLISM; HEART-DISEASE; SPHYNX CAT; SURVIVAL; PREVALENCE;

D O I：

10.1111/jvim.15122

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

BackgroundHypertrophic cardiomyopathy is the most prevalent heart disorder in cats and principal cause of cardiovascular morbidity and mortality. Yet, the impact of preclinical disease is unresolved. Hypothesis/ObjectivesObservational study to characterize cardiovascular morbidity and survival in cats with preclinical nonobstructive (HCM) and obstructive (HOCM) hypertrophic cardiomyopathy and in apparently healthy cats (AH). AnimalsOne thousand seven hundred and thirty client-owned cats (430 preclinical HCM; 578 preclinical HOCM; 722 AH). MethodsRetrospective multicenter, longitudinal, cohort study. Cats from 21 countries were followed through medical record review and owner or referring veterinarian interviews. Data were analyzed to compare long-term outcomes, incidence, and risk for congestive heart failure (CHF), arterial thromboembolism (ATE), and cardiovascular death. ResultsDuring the study period, CHF, ATE, or both occurred in 30.5% and cardiovascular death in 27.9% of 1008 HCM/HOCM cats. Risk assessed at 1, 5, and 10 years after study entry was 7.0%/3.5%, 19.9%/9.7%, and 23.9%/11.3% for CHF/ATE, and 6.7%, 22.8%, and 28.3% for cardiovascular death, respectively. There were no statistically significant differences between HOCM compared with HCM for cardiovascular morbidity or mortality, time from diagnosis to development of morbidity, or cardiovascular survival. Cats that developed cardiovascular morbidity had short survival (meanstandard deviation, 1.3 +/- 1.7 years). Overall, prolonged longevity was recorded in a minority of preclinical HCM/HOCM cats with 10% reaching 9-15 years. Conclusions and Clinical ImportancePreclinical HCM/HOCM is a global health problem of cats that carries substantial risk for CHF, ATE, and cardiovascular death. This finding underscores the need to identify therapies and monitoring strategies that decrease morbidity and mortality.

引用

页码：930 / 943

页数：14

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