Genetics of thyroid nodules and thyroid carcinoma

被引：0

作者：

Fuehrer, D. ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Klinikum Essen, Klin Endokrinol Diabetol & Stoffwechsel, Hufelandstr 55, D-45147 Essen, Germany

来源：

INTERNIST | 2018年 / 59卷 / 07期

关键词：

Thyroid tumor; Thyroid cancer; Molecular pathology; Somatic mutation; Oncogene addiction; TERT PROMOTER MUTATIONS; BRAF V600E; MOLECULAR PATHOGENESIS; ONCOGENIC MUTATIONS; CANCER; THERAPY; REVEALS; FUSION; RAS; ALK;

D O I：

10.1007/s00108-018-0454-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid nodules are heterogeneous tumors with variable genetic signatures. Thyroid cancers are monoclonal lesions with a defined histomorphology that largely depends on the underlying somatic mutation. While the mutation rate is generally low in differentiated thyroid cancers, poorly differentiated and anaplastic thyroid cancers show a high mutation load. The identification of somatic mutations in fine needle aspirates can be helpful for the differential diagnostics of thyroid nodules; however, a prognostic contribution is less certain. The molecular pathology of thyroid tumors is helpful for the development of targeted therapies and may infer novel immuno-oncological concepts for advanced aggressive thyroid cancers.

引用

页码：674 / 680

页数：7

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