Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia

被引：0
作者：
Klonoff, David C. [1 ]
Messler, Jordan [2 ]
Valk, Timothy [3 ]
Jagannathan, Ram [4 ]
Pasquel, Francisco J. [4 ]
Umpierrez, Guillermo E. [4 ]
机构：
[1] Mills Peninsula Med Ctr, San Mateo, CA USA
[2] Glytec, Waltham, MA USA
[3] Admetsys Corp, Div Res, Winter Pk, FL USA
[4] Emory Univ, Sch Med, Atlanta, GA USA
来源：
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY | 2021年 / 15卷 / 05期
关键词：
diabetes; COVID-19; hospital; clinical trial; antiviral; hyperglycemia;
D O I：
10.1177/19322968211013369
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Complications of Coronavirus Disease 2019 (COVID-19) occur with increased frequency in people admitted to the hospital with diabetes or hyperglycemia. The increased risk for COVID-19 infections in the presence of these metabolic conditions is in part due to overlapping pathophysiologic features of COVID-19, diabetes, and glucose control. Various antiviral treatments are being tested in COVID-19 patients. We believe that in these trials, it will be useful to evaluate treatment effect differences in patients stratified according to whether they have diabetes or hyperglycemia. In this way, it will be possible to better facilitate development of antiviral treatments that are most specifically beneficial for the large subset of COVID-19 patients who have diabetes or hyperglycemia.
引用
收藏
页码：1181 / 1187
页数：7
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