Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia

被引：0
作者：
Klonoff, David C. [1 ]
Messler, Jordan [2 ]
Valk, Timothy [3 ]
Jagannathan, Ram [4 ]
Pasquel, Francisco J. [4 ]
Umpierrez, Guillermo E. [4 ]
机构：
[1] Mills Peninsula Med Ctr, San Mateo, CA USA
[2] Glytec, Waltham, MA USA
[3] Admetsys Corp, Div Res, Winter Pk, FL USA
[4] Emory Univ, Sch Med, Atlanta, GA USA
来源：
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY | 2021年 / 15卷 / 05期
关键词：
diabetes; COVID-19; hospital; clinical trial; antiviral; hyperglycemia;
D O I：
10.1177/19322968211013369
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Complications of Coronavirus Disease 2019 (COVID-19) occur with increased frequency in people admitted to the hospital with diabetes or hyperglycemia. The increased risk for COVID-19 infections in the presence of these metabolic conditions is in part due to overlapping pathophysiologic features of COVID-19, diabetes, and glucose control. Various antiviral treatments are being tested in COVID-19 patients. We believe that in these trials, it will be useful to evaluate treatment effect differences in patients stratified according to whether they have diabetes or hyperglycemia. In this way, it will be possible to better facilitate development of antiviral treatments that are most specifically beneficial for the large subset of COVID-19 patients who have diabetes or hyperglycemia.
引用
收藏
页码：1181 / 1187
页数：7
相关论文
共 56 条
  • [1] Impact of Diabetes in Patients Diagnosed With COVID-19
    Abu-Farha, Mohamed
    Al-Mulla, Fahd
    Thanaraj, Thangavel Alphonse
    Kavalakatt, Sina
    Ali, Hamad
    Abdul Ghani, Mohammed
    Abubaker, Jehad
    [J]. FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [2] A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19
    Lundgren J.D.
    Grund B.
    Barkauskas C.E.
    Holland T.L.
    Gottlieb R.L.
    Sandkovsky U.
    Brown S.M.
    Knowlton K.U.
    Self W.H.
    Files D.C.
    Jain M.K.
    Benfield T.
    Bowdish M.E.
    Leshnower B.G.
    Baker J.V.
    Jensen J.-U.
    Gardner E.M.
    Ginde A.A.
    Harris E.S.
    Johansen I.S.
    Markowitz N.
    Matthay M.A.
    Østergaard L.
    Chang C.C.
    Davey V.J.
    Goodman A.
    Higgs E.S.
    Murray D.D.
    Murray T.A.
    Paredes R.
    Parmar M.K.B.
    Phillips A.N.
    Reilly C.
    Sharma S.
    Dewar R.L.
    Teitelbaum M.
    Wentworth D.
    Cao H.
    Klekotka P.
    Babiker A.G.
    Gelijns A.C.
    Kan V.L.
    Polizzotto M.N.
    Thompson B.T.
    Lane H.C.
    Neaton J.D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (10) : 905 - 914
  • [3] Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severeCOVID-19 in type 2 diabetes
    Alzaid, Fawaz
    Julla, Jean-Baptiste
    Diedisheim, Marc
    Potier, Charline
    Potier, Louis
    Velho, Gilberto
    Gaborit, Benedicte
    Manivet, Philippe
    Germain, Stephane
    Vidal-Trecan, Tiphaine
    Roussel, Ronan
    Riveline, Jean-Pierre
    Dalmas, Elise
    Venteclef, Nicolas
    Gautier, Jean-Francois
    [J]. EMBO MOLECULAR MEDICINE, 2020, 12 (10)
  • [4] COVID-19 in people with diabetes: understanding the reasons for worse outcomes
    Apicella, Matteo
    Campopiano, Maria Cristina
    Mantuano, Michele
    Mazoni, Laura
    Coppelli, Alberto
    Prato, Stefano Del
    [J]. LANCET DIABETES & ENDOCRINOLOGY, 2020, 8 (09) : 782 - 792
  • [5] Global aspects of viral glycosylation
    Bagdonaite, Ieva
    Wandall, Hans H.
    [J]. GLYCOBIOLOGY, 2018, 28 (07) : 443 - 467
  • [6] Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease
    Baker, EH
    Janaway, CH
    Philips, BJ
    Brennan, AL
    Baines, DL
    Wood, DM
    Jones, PW
    [J]. THORAX, 2006, 61 (04) : 284 - 289
  • [7] Remdesivir for the Treatment of Covid-19-Final Report
    Beigel, John H.
    Tomashek, Kay M.
    Dodd, Lori E.
    Mehta, Aneesh K.
    Zingman, Barry S.
    Kalil, Andre C.
    Hohmann, Elizabeth
    Chu, Helen Y.
    Luetkemeyer, Annie
    Kline, Susan
    de Castilla, Diego Lopez
    Finberg, Robert W.
    Dierberg, Kerry
    Tapson, Victor
    Hsieh, Lanny
    Patterson, Thomas F.
    Paredes, Roger
    Sweeney, Daniel A.
    Short, William R.
    Touloumi, Giota
    Lye, David Chien
    Ohmagari, Norio
    Oh, Myoung-don
    Ruiz-Palacios, Guillermo M.
    Benfield, Thomas
    Faetkenheuer, Gerd
    Kortepeter, Mark G.
    Atmar, Robert L.
    Creech, C. Buddy
    Lundgren, Jens
    Babiker, Abdel G.
    Pett, Sarah
    Neaton, James D.
    Burgess, Timothy H.
    Bonnett, Tyler
    Green, Michelle
    Makowski, Mat
    Osinusi, Anu
    Nayak, Seema
    Lane, H. Clifford
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (19) : 1813 - 1826
  • [8] BENCHMARKING GLYCEMIC CONTROL IN US HOSPITALS
    Bersoux, Sophie
    Cook, Curtiss B.
    Kongable, Gail L.
    Shu, Jianfen
    Zito, Denise R.
    [J]. ENDOCRINE PRACTICE, 2014, 20 (09) : 876 - 883
  • [9] TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
    Bestle, Dorothea
    Heindl, Miriam Ruth
    Limburg, Hannah
    Thuy Van Lam Van
    Pilgram, Oliver
    Moulton, Hong
    Stein, David A.
    Hardes, Kornelia
    Eickmann, Markus
    Dolnik, Olga
    Rohde, Cornelius
    Klenk, Hans-Dieter
    Garten, Wolfgang
    Steinmetzer, Torsten
    Boettcher-Friebertshaeuser, Eva
    [J]. LIFE SCIENCE ALLIANCE, 2020, 3 (09)
  • [10] Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States
    Bode, Bruce
    Garrett, Valerie
    Messler, Jordan
    McFarland, Raymie
    Crowe, Jennifer
    Booth, Robby
    Klonoff, David C.
    [J]. JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY, 2020, 14 (04): : 813 - 821
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