Ursolic Acid and Oleanolic Acid Suppress Preneoplastic Lesions Induced by 1,2-Dimethylhydrazine in Rat Colon

被引：61

作者：

Furtado, Ricardo A. ^{[1
]}

Rodrigues, Erlon P. ^{[1
]}

Araujo, Felipe R. R. ^{[1
]}

Oliveira, Wendel L. ^{[1
]}

Furtado, Michelle A. ^{[1
]}

Castro, Marcio B. ^{[2
]}

Cunha, Wilson R. ^{[1
]}

Tavares, Denise C. ^{[1
]}

机构：

[1] Univ Franca, Franca, SP, Brazil

[2] Univ Brasilia, Brasilia, DF, Brazil

来源：

TOXICOLOGIC PATHOLOGY | 2008年 / 36卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

ursolic acid; oleanolic acid; aberrant crypt foci;

D O I：

10.1177/0192623308317423

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Ursolic acid (UA) and oleanolic acid (OA) are pentacyclic triterpenoid compounds found in plants used in the human diet and in medicinal herbs, in the form of aglycones or as the free acid. These compounds are known for their hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, antioxidant, and antifertility activities. In the present study, we evaluated the effects of UA and OA on the formation of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in the colon of the male Wistar rat. The animals received subcutaneous (sc) injections of DMH (40 mg/kg body weight) twice a week for two weeks to induce ACF. UA, OA and a mixture of UA and OA were administered to the rats five times a week for four weeks by gavage at doses of 25 mg/kg body weight/day each, during and after DMH treatment. All animals were sacrificed in week 5 for the evaluation of ACF. The results showed a significant reduction in the frequency of ACF in the group treated with the triterpenoid compounds plus DMH when compared to those treated with DMH alone, suggesting that UA and OA suppress the formation of ACF and have a protective effect against colon carcinogenesis.

引用

页码：576 / 580

页数：5

共 39 条

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