Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

被引：179

作者：

Lutterbach, B ^{[1
]}

Hiebert, SW ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

来源：

GENE | 2000年 / 245卷 / 02期

关键词：

deacetylation; myeloid; runt; transcriptional repression;

D O I：

10.1016/S0378-1119(00)00014-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal translocations affecting the AML-1 gene are among the most frequent aberrations found in acute leukemia. Because the AML-1 transcription factor is a critical regulator of hematopoeitic cell development, normal homeostasis is disrupted in cells containing these translocations. In this review we describe the mechanisms of transcriptional activation and repression by AML-1 and how this transcriptional control is disrupted by the chromosomal translocations that affect AML-1. Finally, we discuss how the mechanism of transcriptional repression by these chromosomal translocation fusion proteins is a possible target of therapeutic intervention in acute leukemia. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：223 / 235

页数：13

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