Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

被引:67
作者
Reeves, Kaitlin C. [1 ,2 ]
Shah, Nikhil [1 ,3 ]
Munoz, Braulio [1 ]
Atwood, Brady K. [1 ,4 ]
机构
[1] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 47405 USA
[2] Med Univ South Carolina, Charleston Alcohol Res Ctr, Dept Neurosci, Charleston, SC USA
[3] Indiana Univ Sch Med, Med Scientist Training Program, Indianapolis, IN USA
[4] Indiana Univ, Stark Neurosci Res Inst, Sch Med, Indianapolis, IN 47405 USA
基金
美国国家卫生研究院;
关键词
opioid; synaptic plasticity; receptor signal transduction; neurotransmission; glutamate; GABA; VENTRAL TEGMENTAL AREA; LONG-TERM POTENTIATION; ROSTRAL VENTROMEDIAL MEDULLA; INHIBITORY SYNAPTIC-TRANSMISSION; PERIAQUEDUCTAL GREY NEURONS; HYPOTHALAMIC PROOPIOMELANOCORTIN NEURONS; INCREASES INTRINSIC EXCITABILITY; VENTROLATERAL ORBITAL CORTEX; NUCLEUS-TRACTUS-SOLITARIUS; LOCUS-COERULEUS NEURONS;
D O I
10.3389/fnmol.2022.919773
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons. However, opioid receptor-mediated regulation of neuronal function and synaptic transmission is not uniform in expression pattern and mechanism across the brain. The localization of receptors within specific cell types and neurocircuits determine the effects that endogenous and exogenous opioids have on brain function. In this review we will explore the similarities and differences in opioid receptor-mediated regulation of neurotransmission across different brain regions. We discuss how future studies can consider potential cell-type, regional, and neural pathway-specific effects of opioid receptors in order to better understand how opioid receptors modulate brain function.
引用
收藏
页数:28
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