One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model

被引：166
作者：
Fort, M. [1 ]
Sibila, M. [1 ]
Perez-Martin, E. [1 ]
Nofrarias, M. [1 ]
Mateu, E. [1 ,2 ]
Segales, J. [1 ,2 ]
机构：
[1] Univ Autonoma Barcelona, IRTA, CReSA, E-08193 Barcelona, Spain
[2] Univ Autonoma Barcelona, Fac Vet, Dept Sanitat & Anat Anim, E-08193 Barcelona, Spain
来源：
VACCINE | 2009年 / 27卷 / 30期
关键词：
Porcine circovirus type 2 (PCV2); Postweaning multisystemic wasting syndrome (PMWS); Vaccine; Cell-mediated immunity; IFN-gamma; MULTISYSTEMIC WASTING SYNDROME; REAL-TIME PCR; TYPE-2; PCV2; EXPERIMENTAL-INFECTION; SYNDROME PMWS; MATERNAL ANTIBODIES; PROTECTIVE IMMUNITY; AFFECTED PIGS; PROTEINS; DENMARK;
D O I：
10.1016/j.vaccine.2009.04.028
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immunogenicity and efficacy generated by one dose of a PCV2 sub-unit vaccine (Porcilis PCV (R)) were evaluated in 3-week-old conventional piglets. Vaccination induced both humoral and cell-mediated responses against PCV2, which were increased after the challenge with a PCV2 genotype "b" isolate. High levels of maternally derived antibodies (IPMA >= 10 log(2)) at the time of vaccination were found to interfere with the active seroconversion, whereas titres below 8 log(2) allowed the development of a proper antibody response. Nevertheless, the immunity induced by one dose of the product was partly protective against PCV2 infection, since viremia, shedding and viral load in tissues were significantly reduced in vaccinated pigs compared to controls. (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：4031 / 4037
页数：7
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