Making or breaking the heart: From lineage determination to morphogenesis

被引：462

作者：

Srivastava, Deepak

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

CELL | 2006年 / 126卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that are relevant for childhood and adult heart disease and the growing field of stem cell biology. This review will consider our current understanding of cardiac cell-fate determination and cardiogenesis - largely derived from developmental studies in model organisms and human genetic approaches - and examine future implications for diagnosis, prevention, and treatment of heart disease in the young and old.

引用

页码：1037 / 1048

页数：12

共 105 条

[101] The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation [J].