The Alleviating Pain Effect of Aqueous Extract from Tong-Xie-Yao-Fang, on Experimental Visceral Hypersensitivity and Its Mechanism

被引：25

作者：

Hu, Xu-Guang ^{[1
,2
,3
]}

Xu, Di ^{[1
,4
]}

Zhao, Yue ^{[1
]}

Yang, Xiang-Bo ^{[2
,3
]}

Meng, Jiang ^{[1
,2
,3
]}

Shen, Han ^{[1
,2
,3
]}

Guo, Jiao ^{[1
]}

机构：

[1] Guangdong Pharmaceut Univ, Guangzhou 510006, Guangdong, Peoples R China

[2] S China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

[3] S China Normal Univ, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

[4] S China Agr Univ, Guangzhou 510642, Guangdong, Peoples R China

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2009年 / 32卷 / 06期

关键词：

visceral hypersensitivity; Tong-Xie-Yao-Fang; serotonin; corticotrophin-releasing factor; substance P; IRRITABLE-BOWEL-SYNDROME; SEROTONIN; RATS; INTESTINE; MODEL;

D O I：

10.1248/bpb.32.1075

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tong-Xie-Yao-Fang (TXYF) is a prescription in traditional chinese medicine (TCM), used for relieving abdominal pain associated with irritable bowel syndrome. The aim of the present study was to investigate the effects and mechanism of TXYF on experimental visceral hypersensitivity (VH) models. TXVF affected the abdominal withdrawal reflex produced by colonic distention in maternal separation-induced visceral hypersensitivity rats, in a dosage-dependent manner. TXYF significantly decreased serotonin (5-HT) levels in serum and corticotrophin releasing factor (CRF) concentrations in the brain. Moreover, it was found that VH alleviation by TXVF was dependent on the substance P (SP) expression in the colon mucosa. These results suggest that TXVF attenuates behavioral hyperalgesia by regulating substance associated with the brain-gut axis, including decreasing the expression of 5-HT and SP in the periphery and that of CRF in the center.

引用

页码：1075 / 1079

页数：5

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